Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 3821..4404 Replicon plasmid unnamed1
Accession NZ_CP095097
Organism Staphylococcus sp. IVB6181

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MUA90_RS13530 Protein ID WP_103213364.1
Coordinates 4066..4404 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MUA90_RS13525 Protein ID WP_262588876.1
Coordinates 3821..4069 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA90_RS13505 (MUA90_13520) 788..1579 + 792 WP_105980564.1 ParA family protein -
MUA90_RS13510 (MUA90_13525) 1585..1899 + 315 WP_262588874.1 hypothetical protein -
MUA90_RS13515 (MUA90_13530) 2032..2367 + 336 Protein_3 replication initiator protein A -
MUA90_RS13520 (MUA90_13535) 2398..2646 - 249 WP_262588875.1 hypothetical protein -
MUA90_RS13525 (MUA90_13540) 3821..4069 + 249 WP_262588876.1 AbrB family transcriptional regulator Antitoxin
MUA90_RS13530 (MUA90_13545) 4066..4404 + 339 WP_103213364.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA90_RS13535 (MUA90_13550) 4546..5221 + 676 WP_262588877.1 IS6 family transposase -
MUA90_RS13540 (MUA90_13555) 5529..5640 + 112 Protein_8 hypothetical protein -
MUA90_RS13545 (MUA90_13560) 5894..6160 + 267 WP_201415791.1 helix-turn-helix transcriptional regulator -
MUA90_RS13550 (MUA90_13565) 6200..6505 + 306 WP_262588878.1 hypothetical protein -
MUA90_RS13555 (MUA90_13570) 6771..8093 - 1323 WP_262586296.1 ISL3 family transposase -
MUA90_RS13560 (MUA90_13575) 8224..8316 - 93 Protein_12 RepB family plasmid replication initiator protein -
MUA90_RS13565 (MUA90_13580) 8363..8476 + 114 Protein_13 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..33779 33779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13063.17 Da        Isoelectric Point: 9.6568

>T241314 WP_103213364.1 NZ_CP095097:4066-4404 [Staphylococcus sp. IVB6181]
MSIKQFDIYYIDLDPTRGREKQKIRPCLIVNNKMTIDGTNFVWALPITNREKRYPLDIELKTKKGLVTGVIDTLQIRALD
LSVREHNYKDELQDNLKNVVLQAIQTYLKPSS

Download         Length: 339 bp

>T241314 NZ_LT991955:c196529-196242 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGTATAGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9221.36 Da        Isoelectric Point: 4.8780

>AT241314 WP_262588876.1 NZ_CP095097:3821-4069 [Staphylococcus sp. IVB6181]
MIKTSERIFKSGNSRAISLSKQTIQLADFEVGDKVEVSEINGGLFIKKKEESIEDEITNFFKNGGRYTESEIDFGKSVGR
EI

Download         Length: 249 bp

>AT241314 NZ_LT991955:c196768-196529 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References