Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1021331..1021845 Replicon chromosome
Accession NZ_CP095096
Organism Staphylococcus sp. IVB6181

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA90_RS04775 Protein ID WP_031262808.1
Coordinates 1021495..1021845 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA90_RS04770 Protein ID WP_105994297.1
Coordinates 1021331..1021498 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA90_RS04745 (MUA90_04745) 1017232..1017696 + 465 WP_162912126.1 PH domain-containing protein -
MUA90_RS04750 (MUA90_04750) 1017689..1019188 + 1500 WP_262588534.1 PH domain-containing protein -
MUA90_RS04755 (MUA90_04755) 1019157..1019660 + 504 WP_262588535.1 PH domain-containing protein -
MUA90_RS04760 (MUA90_04760) 1019661..1020014 + 354 WP_114602967.1 holo-ACP synthase -
MUA90_RS04765 (MUA90_04765) 1020096..1021250 + 1155 WP_262588536.1 alanine racemase -
MUA90_RS04770 (MUA90_04770) 1021331..1021498 + 168 WP_105994297.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA90_RS04775 (MUA90_04775) 1021495..1021845 + 351 WP_031262808.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA90_RS04780 (MUA90_04780) 1022136..1023137 + 1002 WP_262588537.1 PP2C family protein-serine/threonine phosphatase -
MUA90_RS04785 (MUA90_04785) 1023213..1023539 + 327 WP_114602971.1 anti-sigma factor antagonist -
MUA90_RS04790 (MUA90_04790) 1023541..1024020 + 480 WP_262588538.1 anti-sigma B factor RsbW -
MUA90_RS04795 (MUA90_04795) 1023995..1024765 + 771 WP_105994293.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.09 Da        Isoelectric Point: 10.0474

>T241313 WP_031262808.1 NZ_CP095096:1021495-1021845 [Staphylococcus sp. IVB6181]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Download         Length: 351 bp

>T241313 NZ_LT991955:93347-94672 [Enterobacter hormaechei subsp. steigerwaltii]
ATGAGCCGGAAACAGCAGCGTCTGGCAATCTGGATGAACGGAATCAAAGTCGGATACTGGGAAAAAAGTAAAGGGGTAGA
CAGCTTACAATACCTTCCTGACTGGAGTGCAGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTCCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTTCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACAGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGCATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGCGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGAACAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAAACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAAGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAGTTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCACTCTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTTGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6241.78 Da        Isoelectric Point: 3.6836

>AT241313 WP_105994297.1 NZ_CP095096:1021331-1021498 [Staphylococcus sp. IVB6181]
MSTFNQNRTYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLAFDKDE

Download         Length: 168 bp

>AT241313 NZ_LT991955:93049-93342 [Enterobacter hormaechei subsp. steigerwaltii]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGTTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGGGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCTATCCTGGGCGTAAAAATCAGCTTCTCCTCGACAACCGCCTCTTCAGAGGGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References