Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1008030..1008544 Replicon chromosome
Accession NZ_CP095096
Organism Staphylococcus sp. IVB6181

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA90_RS04705 Protein ID WP_262588529.1
Coordinates 1008338..1008544 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA90_RS04700 Protein ID WP_262588528.1
Coordinates 1008030..1008323 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA90_RS04680 (MUA90_04680) 1003612..1004121 + 510 WP_262588526.1 GNAT family N-acetyltransferase -
MUA90_RS04685 (MUA90_04685) 1004245..1005564 + 1320 WP_262586250.1 ISL3 family transposase -
MUA90_RS04690 (MUA90_04690) 1005710..1006363 - 654 WP_262588527.1 HD domain-containing protein -
MUA90_RS04695 (MUA90_04695) 1006386..1007867 - 1482 WP_114602957.1 cardiolipin synthase -
MUA90_RS04700 (MUA90_04700) 1008030..1008323 + 294 WP_262588528.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA90_RS04705 (MUA90_04705) 1008338..1008544 + 207 WP_262588529.1 heavy metal-associated domain-containing protein Toxin
MUA90_RS04710 (MUA90_04710) 1008564..1008770 + 207 WP_114602959.1 copper ion binding protein -
MUA90_RS04715 (MUA90_04715) 1008864..1011062 + 2199 WP_262588530.1 heavy metal translocating P-type ATPase -
MUA90_RS04720 (MUA90_04720) 1011137..1011277 + 141 WP_023016106.1 Lmo0850 family protein -
MUA90_RS04725 (MUA90_04725) 1011350..1012558 - 1209 WP_262588531.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1004245..1005564 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(5-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7787.80 Da        Isoelectric Point: 4.0857

>T241312 WP_262588529.1 NZ_CP095096:1008338-1008544 [Staphylococcus sp. IVB6181]
MQTSVIRIGGMETIEQQETLKEHLEAMIGVYEVQVDLDTNEVKASFKTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T241312 NZ_LT991954:c4648063-4647653 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGTTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11089.82 Da        Isoelectric Point: 6.9684

>AT241312 WP_262588528.1 NZ_CP095096:1008030-1008323 [Staphylococcus sp. IVB6181]
MAKVDKVHHSEQIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVDDGNP
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT241312 NZ_LT991954:c4648310-4648044 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References