Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3108..3736 Replicon plasmid unnamed
Accession NZ_CP095095
Organism Flavonifractor plautii strain VE303-08

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K5I25_RS23285 Protein ID WP_246961290.1
Coordinates 3108..3509 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K5I25_RS23290 Protein ID WP_246961292.1
Coordinates 3506..3736 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5I25_RS23255 (K5I25_23255) 260..550 - 291 WP_246961276.1 hypothetical protein -
K5I25_RS23260 (K5I25_23260) 543..1319 - 777 WP_246961279.1 AAA family ATPase -
K5I25_RS23265 (K5I25_23265) 1530..2042 + 513 WP_246961282.1 hypothetical protein -
K5I25_RS23270 (K5I25_23270) 2184..2432 - 249 WP_246961284.1 hypothetical protein -
K5I25_RS23275 (K5I25_23275) 2451..2723 - 273 WP_246961286.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
K5I25_RS23280 (K5I25_23280) 2710..2982 - 273 WP_246961288.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K5I25_RS23285 (K5I25_23285) 3108..3509 - 402 WP_246961290.1 type II toxin-antitoxin system VapC family toxin Toxin
K5I25_RS23290 (K5I25_23290) 3506..3736 - 231 WP_246961292.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K5I25_RS23295 (K5I25_23295) 3775..5190 - 1416 WP_246961294.1 hypothetical protein -
K5I25_RS23300 (K5I25_23300) 5187..5471 - 285 WP_246961297.1 hypothetical protein -
K5I25_RS23305 (K5I25_23305) 5963..6739 - 777 WP_246961300.1 hypothetical protein -
K5I25_RS23310 (K5I25_23310) 6750..7772 - 1023 WP_246961303.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..21828 21828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(9-49)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14899.19 Da        Isoelectric Point: 4.7840

>T241311 WP_246961290.1 NZ_CP095095:c3509-3108 [Flavonifractor plautii]
MTYMLDTNICIYSMKKKPEKVLNRFREELDGGLCISSITLAELEYGMKHSSDPVRNEQALLRFLAPLSILPFGAGAAAEY
GEIRAYLQSRGTPIGPLDMLIAAHARAEGIILVTNNVREFERVPDLELENWAE

Download         Length: 402 bp

>T241311 NZ_LT991954:4420795-4421094 [Enterobacter hormaechei subsp. steigerwaltii]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATCCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8734.86 Da        Isoelectric Point: 4.4367

>AT241311 WP_246961292.1 NZ_CP095095:c3736-3506 [Flavonifractor plautii]
METAKIFENGRSQAVRLPKKFRFKVDEVIVQQLGDAVLLVPKESLWQTFMDGVNSFTSDIFEDGRDQGVQEERESL

Download         Length: 231 bp

>AT241311 NZ_LT991954:4421105-4421470 [Enterobacter hormaechei subsp. steigerwaltii]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCATTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References