Detailed information of TA system TA241310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-relB/VapC-DinJ
• Location: 2710..3509
• Replicon: plasmid unnamed
• Accession: NZ_CP095095
• Organism: Flavonifractor plautii strain VE303-08

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K5I25_RS23285
• Protein ID: WP_246961290.1
• Coordinates: 3108..3509 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K5I25_RS23280
• Protein ID: WP_246961288.1
• Coordinates: 2710..2982 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5I25_RS23255 (K5I25_23255)	260..550	-	291	WP_246961276.1	hypothetical protein	-
K5I25_RS23260 (K5I25_23260)	543..1319	-	777	WP_246961279.1	AAA family ATPase	-
K5I25_RS23265 (K5I25_23265)	1530..2042	+	513	WP_246961282.1	hypothetical protein	-
K5I25_RS23270 (K5I25_23270)	2184..2432	-	249	WP_246961284.1	hypothetical protein	-
K5I25_RS23275 (K5I25_23275)	2451..2723	-	273	WP_246961286.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
K5I25_RS23280 (K5I25_23280)	2710..2982	-	273	WP_246961288.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K5I25_RS23285 (K5I25_23285)	3108..3509	-	402	WP_246961290.1	type II toxin-antitoxin system VapC family toxin	Toxin
K5I25_RS23290 (K5I25_23290)	3506..3736	-	231	WP_246961292.1	type II toxin-antitoxin system VapB family antitoxin	-
K5I25_RS23295 (K5I25_23295)	3775..5190	-	1416	WP_246961294.1	hypothetical protein	-
K5I25_RS23300 (K5I25_23300)	5187..5471	-	285	WP_246961297.1	hypothetical protein	-
K5I25_RS23305 (K5I25_23305)	5963..6739	-	777	WP_246961300.1	hypothetical protein	-
K5I25_RS23310 (K5I25_23310)	6750..7772	-	1023	WP_246961303.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..21828	21828

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-85)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14899.19 Da
• Isoelectric Point: 4.7840

>T241310 WP_246961290.1 NZ_CP095095:c3509-3108 [Flavonifractor plautii]
MTYMLDTNICIYSMKKKPEKVLNRFREELDGGLCISSITLAELEYGMKHSSDPVRNEQALLRFLAPLSILPFGAGAAAEY
GEIRAYLQSRGTPIGPLDMLIAAHARAEGIILVTNNVREFERVPDLELENWAE

Nucleotide

• Length: 402 bp

>T241310 NZ_LT991954:4339249-4339578 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCAAACCTTATCATCACACTCGACACGGGCGACTCAGCCCAATCTGTCACCCGTTAAAACCTGGCAACGGCTGCTGAC
TCATCTGTTATCGCAGCACTATGGCCTGAGGTTGAATGACACACCGTTCAGTAATGAAACCACCATACGAGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAGTACGGGCTTGTCCGTATCGATCGGAAGGGATTT
TCATGGCAAGAACAAACCCCGTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10094.43 Da
• Isoelectric Point: 4.2917

>AT241310 WP_246961288.1 NZ_CP095095:c2982-2710 [Flavonifractor plautii]
MANTNINIRMDTDLKKQFEAFCADMGMTMTTAFNVFARKAVREYRIPFEVGGEVPNDDTKKAMEDAQKGIGMSKGFSSVE
ELMEELNADD

Nucleotide

• Length: 273 bp

>AT241310 NZ_LT991954:4338852-4339211 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCAGAACACAACACCTGTAGCAAACCATGATATTGCCGAACCCTGGTGGGGACTTAAACCCACCGTCACGCCGTGTCT
TGGCGCACGGCTGGTACAGGAAGGCAACCGGCTGCATTATCTGGCTGACCCGGCAAGTATCACCGGAACATTCAACAATG
AGGATTTACGTCATCTCGACCAGGCGTTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACC
TCCCGCTATCAGCACCGCATCACGCTATATCACAATAGACTGACTTGCGAAGCTGACACACTCGGCTCCTGTGGCTATGT
CTGCATCGCTATTTATCCCGACCAGCCTGAACCCCATTAA