Detailed information of TA system TA241308

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2675220..2675782
• Replicon: chromosome
• Accession: NZ_CP095094
• Organism: Flavonifractor plautii strain VE303-08

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K5I25_RS13215
• Protein ID: WP_131971106.1
• Coordinates: 2675220..2675510 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K5I25_RS13220
• Protein ID: WP_131971108.1
• Coordinates: 2675507..2675782 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5I25_RS13185 (K5I25_13185)	2670653..2671129	+	477	WP_165924327.1	UPF0158 family protein	-
K5I25_RS13190 (K5I25_13190)	2671253..2672167	+	915	WP_154250332.1	ParM/StbA family protein	-
K5I25_RS13195 (K5I25_13195)	2672173..2672568	+	396	WP_131971098.1	hypothetical protein	-
K5I25_RS13200 (K5I25_13200)	2672859..2673554	+	696	WP_131971100.1	response regulator transcription factor	-
K5I25_RS13205 (K5I25_13205)	2674256..2674654	+	399	WP_131971102.1	sigma factor-like helix-turn-helix DNA-binding protein	-
K5I25_RS13210 (K5I25_13210)	2674658..2674840	+	183	WP_131971104.1	helix-turn-helix domain-containing protein	-
K5I25_RS13215 (K5I25_13215)	2675220..2675510	-	291	WP_131971106.1	type II toxin-antitoxin system YafQ family toxin	Toxin
K5I25_RS13220 (K5I25_13220)	2675507..2675782	-	276	WP_131971108.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K5I25_RS13225 (K5I25_13225)	2675971..2676657	-	687	WP_243121464.1	hypothetical protein	-
K5I25_RS13230 (K5I25_13230)	2676704..2677741	-	1038	WP_131971110.1	hypothetical protein	-
K5I25_RS13235 (K5I25_13235)	2678003..2678233	-	231	WP_131971112.1	hypothetical protein	-
K5I25_RS13240 (K5I25_13240)	2678259..2678741	-	483	WP_131971114.1	hypothetical protein	-
K5I25_RS13245 (K5I25_13245)	2678847..2679029	-	183	WP_131971116.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2618374..2690069	71695

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-86)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11329.17 Da
• Isoelectric Point: 9.7282

>T241308 WP_131971106.1 NZ_CP095094:c2675510-2675220 [Flavonifractor plautii]
MRKTKYTVKYTTAFKKDYKRAIKRGLKMELLEQVVELLSMGKPLPDKNRDHDLSGDWVGHRECHIQPDWLLIYRIKDDVL
VLTLARTGTHSDLFDQ

Nucleotide

• Length: 291 bp

>T241308 NZ_LT991954:c3089105-3088620 [Enterobacter hormaechei subsp. steigerwaltii]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACCTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGGAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCAGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10339.85 Da
• Isoelectric Point: 5.1484

>AT241308 WP_131971108.1 NZ_CP095094:c2675782-2675507 [Flavonifractor plautii]
MANTTNFSVRMDKDIKKQCETLYNELGVNLTTAINVFLRQSLRAGGFPFEVRLEQPNKETIAAMLEAERIAKDPSVKAYN
DLDELFADLKK

Nucleotide

• Length: 276 bp

>AT241308 NZ_LT991954:c3089359-3089093 [Enterobacter hormaechei subsp. steigerwaltii]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCGGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA