Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1316201..1316747 Replicon chromosome
Accession NZ_CP095094
Organism Flavonifractor plautii strain VE303-08

Toxin (Protein)


Gene name relE Uniprot ID A0A6I2RGN4
Locus tag K5I25_RS06630 Protein ID WP_024724286.1
Coordinates 1316475..1316747 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6I2RLP7
Locus tag K5I25_RS06625 Protein ID WP_024724287.1
Coordinates 1316201..1316482 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5I25_RS06605 (K5I25_06605) 1311469..1312185 + 717 WP_154250435.1 response regulator transcription factor -
K5I25_RS06610 (K5I25_06610) 1312484..1313002 + 519 WP_154250436.1 sigma-70 family RNA polymerase sigma factor -
K5I25_RS06615 (K5I25_06615) 1313246..1313983 + 738 Protein_1287 exodeoxyribonuclease III -
K5I25_RS06620 (K5I25_06620) 1314032..1316089 + 2058 WP_226923538.1 reverse transcriptase domain-containing protein -
K5I25_RS06625 (K5I25_06625) 1316201..1316482 + 282 WP_024724287.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K5I25_RS06630 (K5I25_06630) 1316475..1316747 + 273 WP_024724286.1 type II toxin-antitoxin system YafQ family toxin Toxin
K5I25_RS06635 (K5I25_06635) 1317405..1318574 + 1170 WP_024724285.1 C39 family peptidase -
K5I25_RS06640 (K5I25_06640) 1318571..1319065 + 495 WP_024724284.1 hypothetical protein -
K5I25_RS06645 (K5I25_06645) 1319333..1320523 - 1191 WP_044943990.1 IS256 family transposase -
K5I25_RS06650 (K5I25_06650) 1320799..1321725 - 927 WP_178792548.1 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1233156..1378598 145442
- flank IS/Tn - - 1319333..1320523 1190


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-87)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10496.04 Da        Isoelectric Point: 7.8785

>T241306 WP_024724286.1 NZ_CP095094:1316475-1316747 [Flavonifractor plautii]
MYNIRPTTKFQRDLKRVKRRGFDISLLTDIIKKLAAGEPLPEKNRDHQMSGDYAGCRECHITPDWLLIYEVDGNELILYL
TRTGSHSDLF

Download         Length: 273 bp

>T241306 NZ_LT991954:c775090-774719 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10541.09 Da        Isoelectric Point: 4.4692

>AT241306 WP_024724287.1 NZ_CP095094:1316201-1316482 [Flavonifractor plautii]
MANTNINIRMDTDLKKQFEAFCADMGMTMTTAFNIFARKAVREYRIPFEISGDVPNAETVEAIQEVKRMKANPSLGKTYS
DVDQMIEELLADV

Download         Length: 282 bp

>AT241306 NZ_LT991954:c775335-775093 [Enterobacter hormaechei subsp. steigerwaltii]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I2RGN4

Antitoxin

Source ID Structure
AlphaFold DB A0A6I2RLP7

References