241303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1784..2372 Replicon plasmid pAB4451
Accession NZ_CP095092
Organism Acinetobacter baumannii strain AB4451

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag MUU69_RS18935 Protein ID WP_000438827.1
Coordinates 1784..2071 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MUU69_RS18940 Protein ID WP_001983304.1
Coordinates 2058..2372 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUU69_RS18920 (MUU69_18920) 166..411 + 246 WP_245113208.1 hypothetical protein -
MUU69_RS18925 (MUU69_18925) 489..1007 + 519 WP_000839337.1 plasmid replication DNA-binding protein -
MUU69_RS18930 (MUU69_18930) 1217..1360 + 144 WP_245113211.1 hypothetical protein -
MUU69_RS18935 (MUU69_18935) 1784..2071 + 288 WP_000438827.1 BrnT family toxin Toxin
MUU69_RS18940 (MUU69_18940) 2058..2372 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MUU69_RS18945 (MUU69_18945) 2500..4906 + 2407 Protein_6 TonB-dependent receptor ZnuD2 -
MUU69_RS18950 (MUU69_18950) 5211..5672 + 462 WP_000761346.1 DIP1984 family protein -
MUU69_RS18955 (MUU69_18955) 5998..6207 - 210 WP_000069474.1 hypothetical protein -
MUU69_RS18960 (MUU69_18960) 6200..6502 - 303 WP_001129974.1 XRE family transcriptional regulator -
MUU69_RS18965 (MUU69_18965) 6495..6851 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11178 11178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T241303 WP_000438827.1 NZ_CP095092:1784-2071 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T241303 NZ_LT985195:c20856-20479 [Pseudomonas syringae]
GTGAAAGGCGTCCTGGTAGACACCTCCGTTTGGGTTGAGCACTTTCGCAACAACAGTCCAGAACTGGTGAACTTGCTCAG
CCAGGACCGGGTACTCATACACCCCATGGTGATCGGAGAACTGGCGTGTGGTACGCCACCTGATCGTTCGAACACCTTGA
CCGACCTTGGCGACCTACGAGGTGCACAACAACCCACGGTGAGTGAAGTCATCGCCTTTCTGAACACCCACAAGCTCTAT
GGCCTGGGCTGTGGGCTGGTGGATATGACGCTCCTGGCCTCCGCGTTATTGAGCGGCACAGCGCTTTGGACGTTAGACAA
GCGCCTGGAGCGTTTGGCTAGTCGCATGGCCGTGTCTTACCAGCCTCCTACTCACTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT241303 WP_001983304.1 NZ_CP095092:2058-2372 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT241303 NZ_LT985195:c21053-20853 [Pseudomonas syringae]
ATGAGAACGACCGTCACCATCGACGATGCGTTGTACCAACGTGCTCTGGAAGTCGCCGATCCGGCGATGGATAAGGCCGA
CCTGTTCCGTGAAGCCGTTCAGACGTTTGTGCGCATTCAAGCAGCTAAACGATTGATGGCCTTAGGGGCCACACTGCCAA
CGATGGAAGACATCGCCCGCCGACACGAGAAGGCACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References