Detailed information of TA system TA241302

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 450610..451263
• Replicon: chromosome
• Accession: NZ_CP095091
• Organism: Acinetobacter baumannii strain AB4451

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MUU69_RS02195
• Protein ID: WP_000607077.1
• Coordinates: 450874..451263 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: MUU69_RS02190
• Protein ID: WP_001288210.1
• Coordinates: 450610..450867 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUU69_RS02170 (MUU69_02170)	446126..447133	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
MUU69_RS02175 (MUU69_02175)	447152..447529	+	378	WP_001216380.1	50S ribosomal protein L17	-
MUU69_RS02180 (MUU69_02180)	447711..449201	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
MUU69_RS02185 (MUU69_02185)	449250..450422	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
MUU69_RS02190 (MUU69_02190)	450610..450867	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
MUU69_RS02195 (MUU69_02195)	450874..451263	+	390	WP_000607077.1	membrane protein	Toxin
MUU69_RS02200 (MUU69_02200)	452033..453118	+	1086	WP_000049106.1	hypothetical protein	-
MUU69_RS02205 (MUU69_02205)	453196..453762	+	567	WP_000651538.1	rhombosortase	-
MUU69_RS02210 (MUU69_02210)	453950..456145	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T241302 WP_000607077.1 NZ_CP095091:450874-451263 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T241302 NZ_LT985194:45558-45740 [Pseudomonas syringae]
ATGAAGTGCAGCGAGTTTCGGCGATGGTTACAGGCTCAAGGCGCTGAGTTCAAAGCGGCCAAGGGCAGTCACTTCAAGGT
GTACTTGAATGGCAAGGCGACCATCTTTGCAGACCACGGCAGCAAGGAAATGCACGAAGGGTTACGCAAAACGATCATCA
AACAGCTGGGCCTCAAGGACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT241302 WP_001288210.1 NZ_CP095091:450610-450867 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT241302 NZ_LT985194:45772-46194 [Pseudomonas syringae]
ATGTATCAGTATCCGCTGACGCAGCATCAAGAACAGACTGGCGTCTGGCTTTCTTGCCCGAACATCCCCGAAATGAACGC
ATCAGGTGAAACCTTGACCGAGGCCCTGGACGAAGCCCTGAACGGTATGGAGTCGGCATTGTCGCTCTATGTCGACCAGC
GCCGAAAAATCCCGCAGGCGTCACTACCAGTCGGTGACGAGCTGGTGATGCACCTGCCTGCGCTGACCGTCGCCAAGATC
ATGCTGTGGAACAGCATGTTGGACAACGGCGTGAGCCGTGCGGAGCTGGCGCGCCGCCTGGGCTGTACGCGGCAAGTCGT
GGATCGGCTGGTGGACTTCCTGCACACCTCGAAAATCGAGCAGGTCGAGCGAGCGCTAGGCCTACTGGGCAGGCGTATCA
CGCTGAGCCTTGAGGCGGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7