Detailed information of TA system TA241301

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1955648..1956118
• Replicon: chromosome
• Accession: NZ_CP095090
• Organism: Staphylococcus epidermidis strain SKN25lux

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: MUW37_RS09215
• Protein ID: WP_001829569.1
• Coordinates: 1955930..1956118 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: MUW37_RS09210
• Protein ID: WP_002438963.1
• Coordinates: 1955648..1955905 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW37_RS09175 (MUW37_09175)	1950938..1951093	-	156	WP_001829648.1	hypothetical protein	-
MUW37_RS09180 (MUW37_09180)	1951105..1951293	-	189	WP_244788113.1	hypothetical protein	-
MUW37_RS09185 (MUW37_09185)	1951440..1952639	-	1200	WP_073392450.1	IS110-like element ISSep2 family transposase	-
MUW37_RS09190 (MUW37_09190)	1953236..1953736	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
MUW37_RS09195 (MUW37_09195)	1954007..1954594	-	588	WP_002469329.1	histidine phosphatase family protein	-
MUW37_RS09200 (MUW37_09200)	1954808..1955044	+	237	WP_002457224.1	hypothetical protein	-
MUW37_RS09205 (MUW37_09205)	1955036..1955239	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
MUW37_RS09210 (MUW37_09210)	1955648..1955905	+	258	WP_002438963.1	hypothetical protein	Antitoxin
MUW37_RS09215 (MUW37_09215)	1955930..1956118	+	189	WP_001829569.1	hypothetical protein	Toxin
MUW37_RS09220 (MUW37_09220)	1956308..1956862	+	555	WP_002469327.1	lipoprotein N-acylation protein LnsA	-
MUW37_RS09225 (MUW37_09225)	1956922..1957155	-	234	WP_001829664.1	hypothetical protein	-
MUW37_RS09230 (MUW37_09230)	1957439..1958185	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
MUW37_RS09235 (MUW37_09235)	1958284..1958568	+	285	WP_001829635.1	hypothetical protein	-
MUW37_RS09240 (MUW37_09240)	1958592..1958816	+	225	WP_001829613.1	hypothetical protein	-
MUW37_RS09245 (MUW37_09245)	1959437..1959637	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1945063..1970461	25398

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T241301 WP_001829569.1 NZ_CP095090:1955930-1956118 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T241301 NZ_LT985193:53813-54088 [Pseudomonas syringae]
ATGGAATTGAAGTGGACAAGCAAGGCGCTTTCCGACATTACCAGGCTATACGAGTTTCTGGCCTTGGCGAATCAACCTGC
CGCAGCACGAGTAGTGCAGCAACTCACCACAGCACCTACCACGCTTCTGACTAACCCGCGCATTGGCGAACGCCTAGAGG
AGTTCGAGCCAAAGGACGTACGCCGAATTCAGATCGGCCAATACGAGATGCGTTACGAGATAGCGGATTCAACTATTTAC
CTGCTGCGCCTGTGGCACACCCGCGAAGACCGATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT241301 WP_002438963.1 NZ_CP095090:1955648-1955905 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT241301 NZ_LT985193:53541-53813 [Pseudomonas syringae]
ATGGCAACCACCGCCAAAACCCGATCTGTCACAGCTCACGTTCCGGTTCAGCTGGCGGAAAAAGTCGATTTGATGGCTGA
GCGTCTGGAGCGCTCTAAGAACTGGATCGTCAAGCAAGCCCTGTCTGCTTGGATAGACCAGGAAGAAGAGCGTAGTCGCC
TGACCCGTGAGGCCTTGGCTGATGTTGACGCTGGACGCGTTATTGATCACCAAGCCGTCCAGGCCTGGGCTGACAGTCTT
AGCACCGACACTCCGTTGCCGGTGCCGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3