Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 994502..995304 Replicon chromosome
Accession NZ_CP095090
Organism Staphylococcus epidermidis strain SKN25lux

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MUW37_RS04790 Protein ID WP_002468490.1
Coordinates 995125..995304 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MUW37_RS04785 Protein ID WP_002456349.1
Coordinates 994502..995101 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW37_RS04760 (MUW37_04760) 989603..990325 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MUW37_RS04765 (MUW37_04765) 990803..992002 + 1200 WP_071813246.1 IS110-like element ISSep2 family transposase -
MUW37_RS04770 (MUW37_04770) 992382..992537 + 156 WP_001829854.1 hypothetical protein -
MUW37_RS04775 (MUW37_04775) 992747..993877 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MUW37_RS04780 (MUW37_04780) 993874..994344 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUW37_RS04785 (MUW37_04785) 994502..995101 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MUW37_RS04790 (MUW37_04790) 995125..995304 + 180 WP_002468490.1 SAS053 family protein Toxin
MUW37_RS04795 (MUW37_04795) 995460..995864 + 405 WP_001829818.1 hypothetical protein -
MUW37_RS04800 (MUW37_04800) 996049..997434 + 1386 WP_001829862.1 class II fumarate hydratase -
MUW37_RS04805 (MUW37_04805) 997795..998619 - 825 WP_001829804.1 RluA family pseudouridine synthase -
MUW37_RS04810 (MUW37_04810) 998778..999911 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T241300 WP_002468490.1 NZ_CP095090:995125-995304 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T241300 NZ_LT985193:6924-7196 [Pseudomonas syringae]
GTGCTAGTTGAGTGGCTTCCACAAGCTTTGGAGGCACTGGAGGAAATCGCCGGCTACCTAGCCGAGCGCAACCCTTATGC
TGCCGAGCAGATGCAGGCCACCCTTGAGGCCACGGTCGAGGCTCTCCCCCTGCACCCTTACATCCACCGTCCCGGCCGTG
TTCCAGGAACGCGCGAAGCGGTTGTGCATCCCAACTACCTGGTTGTCTACCGCGTCGGTACAGAGCGCATCAGCATCTTG
GACGTCCTGCACGCCCGCCAAGAGTACCCCTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT241300 WP_002456349.1 NZ_CP095090:994502-995101 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT241300 NZ_LT985193:6749-6934 [Pseudomonas syringae]
ATGAGCATTCAACTTGACCCTCGCGTCTCGGAGTTCGAGACCCAGGAACAGGCCGACAATTACGACCGTTGGTTTCGCCA
GCGTATCGAGCACAGTTTGGCCGATCCGCGTCCACCCGTGCCGCACGATGAAGCAATGGCTCGCGTCAGAGCAATGATCG
AAGCAAAGCGCCGCCGTGCTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References