Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 846256..846785 Replicon chromosome
Accession NZ_CP095090
Organism Staphylococcus epidermidis strain SKN25lux

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MUW37_RS03940 Protein ID WP_001829891.1
Coordinates 846423..846785 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MUW37_RS03935 Protein ID WP_001829931.1
Coordinates 846256..846426 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW37_RS03910 (MUW37_03910) 842080..842559 + 480 WP_002469586.1 PH domain-containing protein -
MUW37_RS03915 (MUW37_03915) 842552..844057 + 1506 WP_002457110.1 PH domain-containing protein -
MUW37_RS03920 (MUW37_03920) 844044..844553 + 510 WP_002457109.1 PH domain-containing protein -
MUW37_RS03925 (MUW37_03925) 844601..844954 + 354 WP_002457108.1 holo-ACP synthase -
MUW37_RS03930 (MUW37_03930) 845021..846169 + 1149 WP_002457107.1 alanine racemase -
MUW37_RS03935 (MUW37_03935) 846256..846426 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUW37_RS03940 (MUW37_03940) 846423..846785 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUW37_RS03945 (MUW37_03945) 847130..848131 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MUW37_RS03950 (MUW37_03950) 848231..848557 + 327 WP_001829952.1 anti-sigma factor antagonist -
MUW37_RS03955 (MUW37_03955) 848559..849032 + 474 WP_002469585.1 anti-sigma B factor RsbW -
MUW37_RS03960 (MUW37_03960) 849007..849777 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T241299 WP_001829891.1 NZ_CP095090:846423-846785 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T241299 NZ_LT985192:c5774951-5774661 [Pseudomonas syringae]
ATGACCTATAACCTCGAATTCGATGCGCGGGCTCTAAAGGAATGGCACAAATTAGGAGATACCGTGCGTCAGCAGCTCAA
GAAAAAGCTGGCTACGATTCTGGTTGCTCCGCGTGTTGAAGCCAATCGTCTGCATGCATTGCCTGACTGCTACAAAATCA
AACTGCGCAGTAGCGGCTATCGGCTGGTTTATCAGGTTATTGACCAAGAGGTTGTGGTCTTCGTGGTTGCGGTAGACAAG
CGTGAACGGGAAGAGGTTTATCGCAAGGCGACGGACCGGCTGGGTAGGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT241299 WP_001829931.1 NZ_CP095090:846256-846426 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT241299 NZ_LT985192:c5775180-5774941 [Pseudomonas syringae]
ATGGCGTCTATCAACGTTCGTATCGACGACGATCTCAAAGCGCGTGCTTACCTCGAGCTGGAAAAGCTTGGCGTCACCCC
CTCGGAGTTGCTGCGCCAAACCCTGCAGTACGTAGCTGAGCGTGGTCAGCTACCCTTCAAGACGGTTCTGATGACAGAGG
AAGACGAAGCGCTGTTGGCAACTGTGCGCGAGCGCCTTGCAGCTCCGCAGCGGGTCAAGGTTTCACTGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References