Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 835071..835580 Replicon chromosome
Accession NZ_CP095090
Organism Staphylococcus epidermidis strain SKN25lux

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MUW37_RS03880 Protein ID WP_001829980.1
Coordinates 835371..835580 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MUW37_RS03875 Protein ID WP_001829893.1
Coordinates 835071..835364 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW37_RS03850 (MUW37_03850) 830079..830867 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
MUW37_RS03855 (MUW37_03855) 830873..831511 + 639 WP_002505076.1 thiamine phosphate synthase -
MUW37_RS03860 (MUW37_03860) 831600..832472 + 873 WP_002470121.1 membrane protein insertase YidC -
MUW37_RS03865 (MUW37_03865) 832578..833231 - 654 WP_001829983.1 HD domain-containing protein -
MUW37_RS03870 (MUW37_03870) 833413..834897 - 1485 WP_002457116.1 cardiolipin synthase -
MUW37_RS03875 (MUW37_03875) 835071..835364 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUW37_RS03880 (MUW37_03880) 835371..835580 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MUW37_RS03885 (MUW37_03885) 835723..835860 + 138 WP_001829949.1 Lmo0850 family protein -
MUW37_RS03890 (MUW37_03890) 835959..837170 - 1212 WP_002457115.1 FtsW/RodA/SpoVE family cell cycle protein -
MUW37_RS03895 (MUW37_03895) 837561..838634 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
MUW37_RS03900 (MUW37_03900) 838646..840001 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T241298 WP_001829980.1 NZ_CP095090:835371-835580 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T241298 NZ_LT985192:c157324-157025 [Pseudomonas syringae]
ATGACGACGATAAAACAGACCTCTACCTATATGGCTTGGGAACGCAGGCTTAAAGACCAGAAGGCCAAAGCTGCAATTGC
CGCTCGTATTTTTAGAGTTGCAAATGGCCTGATGGGTGATGTCTCTCCAGTAGGACAGGGCGTTAGTGAGCTACGGATAC
ACGTTGGCCCTGGTTACCGTGTTTATTTCCAGCAGCGAGGCGATGAACTGATCTTGCTGCTGTGCGGTGGTGACAAGAGC
AGCCAATCCCGAGATATCGAAACAGCCAAGAAACTGGCTGATCAATGGTGGCAAGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT241298 WP_001829893.1 NZ_CP095090:835071-835364 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT241298 NZ_LT985192:c157028-156744 [Pseudomonas syringae]
ATGAAAGAACAAATTTTCGATTACGACCCAGCAGCAGCCCTTGACGGTCCTGAAGCAATCGCGATTTTTATCTCTGATGC
CTTTGAGACGGGGGATGCGGAGTACATCGCGAAGGCTATGGGGGTTGTCGCAAGGGCCAAAGGGATGACCGAGCTTGCGC
GCGAGACAGGTCTGTCTCGAGAGCAGCTTTATCGGTCGTTCAGTAGCAAGGGCAATCCAACCTTAAAAACCATGTTGACG
GTAATGAGAGCCCTGGGCGTGGATATGACAGCTCGAATGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References