Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4131425..4132020 Replicon chromosome
Accession NZ_CP095088
Organism Escherichia coli isolate w264

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag MUK78_RS20265 Protein ID WP_000239579.1
Coordinates 4131425..4131775 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag MUK78_RS20270 Protein ID WP_001223208.1
Coordinates 4131769..4132020 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUK78_RS20245 (4126871) 4126871..4127893 - 1023 WP_001295197.1 ABC transporter permease -
MUK78_RS20250 (4127907) 4127907..4129385 - 1479 WP_231838809.1 sugar ABC transporter ATP-binding protein -
MUK78_RS20255 (4129549) 4129549..4130505 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
MUK78_RS20260 (4130815) 4130815..4131345 + 531 WP_000055072.1 inorganic diphosphatase -
MUK78_RS20265 (4131425) 4131425..4131775 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
MUK78_RS20270 (4131769) 4131769..4132020 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
MUK78_RS20275 (4132232) 4132232..4132573 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
MUK78_RS20280 (4132576) 4132576..4136355 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T241295 WP_000239579.1 NZ_CP095088:c4131775-4131425 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T241295 NZ_LT985188:c3180084-3179803 [Micropruina glycogenica]
GTGATCAGGTCGTTTCGCGACTCGGCAACCGAGCGGCTCTGGTCACGCCAACGGGTCAAGACCATCGACCCACGCATCGA
ACGAGCCGCCCTGCGGAAGCTGGTGATGCTGGATGCCGCTGAGACCCTGGACGACCTGCGCGTGCCACCGGGCAACCGGC
TCGAAGAACTCCGGGGAGACCGGGCCGGCCAGCACAGCATCCGGATCAACCAGCAGTGGAGGATCTGCTTCACCTGGACC
GACGCCGGACCGATCGACGTCGAGATCGTCGACTACCACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT241295 WP_001223208.1 NZ_CP095088:c4132020-4131769 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT241295 NZ_LT985188:c3179793-3179500 [Micropruina glycogenica]
ATGACGACCACTACACCCATCCACCCCGGCGAAATCCTGATGGAGGAGTTCCTCGAGCCGCTCGCAGTCAGCCAGAACCG
GCTCGCCGTCGCAATCGGCGTGCCGCCACGTCGCATCAACGAGATCGTCCACGGCAAGCGCCGCATCACGGCCGACACCG
CACTACGGCTCGCCCGCTACTTCGGCACCACCGACCGGTTCTGGCTCAACCTCCAGATCCGCTACGACCTCGAAGTCGAA
AAGGACCACCTCGGCAACAGCCTCGACCGAATCGAACCACTCGAAGCCGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References