241290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3539902..3540520 Replicon chromosome
Accession NZ_CP095088
Organism Escherichia coli isolate w264

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag MUK78_RS17425 Protein ID WP_001291435.1
Coordinates 3540302..3540520 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag MUK78_RS17420 Protein ID WP_000344800.1
Coordinates 3539902..3540276 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUK78_RS17410 (3534991) 3534991..3536184 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MUK78_RS17415 (3536207) 3536207..3539356 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
MUK78_RS17420 (3539902) 3539902..3540276 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
MUK78_RS17425 (3540302) 3540302..3540520 + 219 WP_001291435.1 HHA domain-containing protein Toxin
MUK78_RS17430 (3540692) 3540692..3541243 + 552 WP_000102564.1 maltose O-acetyltransferase -
MUK78_RS17435 (3541359) 3541359..3541829 + 471 WP_000136192.1 YlaC family protein -
MUK78_RS17440 (3541993) 3541993..3543543 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
MUK78_RS17445 (3543585) 3543585..3543938 - 354 WP_244756202.1 DUF1428 family protein -
MUK78_RS17455 (3544317) 3544317..3544628 + 312 WP_000409911.1 MGMT family protein -
MUK78_RS17460 (3544659) 3544659..3545231 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T241290 WP_001291435.1 NZ_CP095088:3540302-3540520 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T241290 NZ_LT984798:944637-944933 [Desulfovibrio sp. G11]
ATGAGCTATAGCCTGCAGTTTCATGAGCTAGCACTGAAAGAATGGAAAAGGCTTGATTCCAGCATCAGAGAACAGTTTAA
AAAGAAACTGGCAGAACGGTTACAACAGCCGAGAGTTCCCTCATCTGCCCTGTCTGGCATGCGCGATTGCTACAAAATCA
AATTGCGCTCCATTGGGTATCGCCTGGTGTACAAGGTGAATGATGACATTCTCTTTGTAACGGTCATCTCCATTGGCAAG
CGTGAACGCCTTGAGGCATATCGACAAGCCCTACGACGTATGCCCTCTGAAGAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT241290 WP_000344800.1 NZ_CP095088:3539902-3540276 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT241290 NZ_LT984798:944402-944647 [Desulfovibrio sp. G11]
ATGGATTCCATACTCTCCAATATCACCGTTAGCGTCACAGAACTCAAACGGAACTTTGCGAATGTCCTGGCAACTGCCAA
GGATGCGCCGGTGGCAGTTTTGAACCATAACAAGCCAGAGGCCTACCTGTTGTCCGCAAAGCACTACGAAGAAATCCTCG
GAATTCTTGAAGATCTTGAAGACAGAAAGATTGTTGAAAAACGCGAAGATGGCCCTTTTGTCAAGGTAACGCTTGATGAG
CTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References