Detailed information of TA system TA241289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3098973..3099678
• Replicon: chromosome
• Accession: NZ_CP095088
• Organism: Escherichia coli isolate w264

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: MUK78_RS15310
• Protein ID: WP_000539521.1
• Coordinates: 3098973..3099359 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MUK78_RS15315
• Protein ID: WP_001280945.1
• Coordinates: 3099349..3099678 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUK78_RS15290 (3094977)	3094977..3095603	+	627	WP_001295292.1	glutathione S-transferase GstB	-
MUK78_RS15295 (3095600)	3095600..3096715	-	1116	Protein_3005	aldose sugar dehydrogenase YliI	-
MUK78_RS15300 (3096826)	3096826..3097209	-	384	WP_000497137.1	biofilm formation regulator BssR	-
MUK78_RS15305 (3097422)	3097422..3098747	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
MUK78_RS15310 (3098973)	3098973..3099359	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MUK78_RS15315 (3099349)	3099349..3099678	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
MUK78_RS15320 (3099748)	3099748..3101076	-	1329	WP_000086877.1	GGDEF domain-containing protein	-
MUK78_RS15325 (3101084)	3101084..3103432	-	2349	WP_096038021.1	EAL domain-containing protein	-
MUK78_RS15330 (3103610)	3103610..3104521	-	912	WP_001236042.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T241289 WP_000539521.1 NZ_CP095088:3098973-3099359 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T241289 NZ_LT984798:c937764-937468 [Desulfovibrio sp. G11]
ATGAGCTATAGTCTGCAGTTTCATGAGATTGCGCTGAAGGAGTGGAGAAAACTGGATGCCAGCATCCGGGAACAGTTTAA
AAAGAAACTGGCTGAACGTTTGGAACATCCACGGGTTCCTTCATCCGCTTTGTCTGGCATGCGCGATTGCTATAAAATAA
AACTGCGCTCAATTGGATATCGGCTGGTGTACATGGTGGATGATGGCATCCTCTTTGTTACAGTCATTTCCATTGGCAAG
CGTGAACGCCTTGAAGTATATCGGAAGGCTTTGCAACGTGTGACTCCAGAAGAATAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT241289 WP_001280945.1 NZ_CP095088:3099349-3099678 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT241289 NZ_LT984798:c937999-937754 [Desulfovibrio sp. G11]
ATGGATCCTATACACGCCAATATTACAGTGAGTGTCACGGAACTCAAACGCAATTTTGCAAATATTTTGGCTACTGCCAA
GGATGCTCCGGTGGCAGTTTTGAACCACAACAAACCGGAAGCCTACCTTTTGTCCGCAAAGCATTACGAAGAAATCCTTG
GAATCCTTGAAGACCTTGAAGACAAGAAGATCGTCGAAAGCCGCGAGCATGGCCCTTTTGTCACGGTGACGCTTGATGAG
CTATAG

Structures

Toxin

• AlphaFold DB: A0A829GCT6