Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2441105..2441743 Replicon chromosome
Accession NZ_CP095088
Organism Escherichia coli isolate w264

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag MUK78_RS11915 Protein ID WP_000813794.1
Coordinates 2441567..2441743 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MUK78_RS11910 Protein ID WP_001270286.1
Coordinates 2441105..2441521 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUK78_RS11890 (2436257) 2436257..2437198 - 942 WP_001251313.1 ABC transporter permease -
MUK78_RS11895 (2437199) 2437199..2438212 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
MUK78_RS11900 (2438230) 2438230..2439375 - 1146 WP_096037851.1 ABC transporter substrate-binding protein -
MUK78_RS11905 (2439620) 2439620..2441026 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
MUK78_RS11910 (2441105) 2441105..2441521 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
MUK78_RS11915 (2441567) 2441567..2441743 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
MUK78_RS11920 (2441965) 2441965..2442195 + 231 WP_000494244.1 YncJ family protein -
MUK78_RS11925 (2442287) 2442287..2444248 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
MUK78_RS11930 (2444321) 2444321..2444857 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
MUK78_RS11935 (2444949) 2444949..2446124 + 1176 WP_001236261.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T241288 WP_000813794.1 NZ_CP095088:c2441743-2441567 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T241288 NZ_LT984798:805530-805760 [Desulfovibrio sp. G11]
CTGTTTTCTGAAGAACAGTTTTTGAATTTCCAATGGTATCTTTGCCAATGTCCCAGTGCCGGGGATGTGATCCCGGAAAC
TGGAGGCTGTCGTAAAATCCGTTGGAAAGTACCGGGCAAGGGGAAAAGGGGTGGGGCAAGAGTCATTTATTTTTTGCGAA
CCGAGGCTGGGCAGATTGTCCTTGTGGCGGCCTATAGCAAGAATGAGCGTGAAGACGTGCCGCGCCAGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT241288 WP_001270286.1 NZ_CP095088:c2441521-2441105 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT241288 NZ_LT984798:805903-806151 [Desulfovibrio sp. G11]
ATGGTTGACAAGAACGGTGTTGTCATTTCTGAAGAAACAATTTCAAATGAACAACGCCTGTCTTTGGATGCCCGTATCAG
GCTGGGAATGTCCCAACAGCAGTTTGCCAAAATGCTGGGGATTTCTGTTCGCACCCTGCATGATTGGGAACAGGGAAGAC
GGGAGCCTTCAGGGGCTGCCAAGACCTTGCTCTATATTGCGGCACGACACCCTGATATTGTTCAGGAAATTGTGGAGCAG
CGTACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References