Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 804074..804875 Replicon chromosome
Accession NZ_CP095083
Organism Escherichia coli strain EC6868

Toxin (Protein)


Gene name yeeV Uniprot ID U9ZA48
Locus tag MUK76_RS03890 Protein ID WP_001513431.1
Coordinates 804074..804451 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID U9YYT7
Locus tag MUK76_RS03895 Protein ID WP_001513429.1
Coordinates 804498..804875 (-) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUK76_RS03865 (800206) 800206..801189 - 984 WP_001329577.1 KpsF/GutQ family sugar-phosphate isomerase -
MUK76_RS03870 (801999) 801999..802130 - 132 Protein_761 IS110 family transposase -
MUK76_RS03875 (802512) 802512..803354 - 843 WP_001513432.1 DUF4942 domain-containing protein -
MUK76_RS03880 (803439) 803439..803636 - 198 WP_001374283.1 DUF957 domain-containing protein -
MUK76_RS03885 (803648) 803648..804023 - 376 Protein_764 DUF5983 family protein -
MUK76_RS03890 (804074) 804074..804451 - 378 WP_001513431.1 TA system toxin CbtA family protein Toxin
MUK76_RS03895 (804498) 804498..804875 - 378 WP_001513429.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MUK76_RS03900 (805038) 805038..805259 - 222 WP_000692345.1 DUF987 domain-containing protein -
MUK76_RS03905 (805328) 805328..805804 - 477 WP_001186726.1 RadC family protein -
MUK76_RS03910 (805820) 805820..806305 - 486 WP_001513428.1 antirestriction protein -
MUK76_RS03915 (806360) 806360..807178 - 819 WP_001513427.1 DUF932 domain-containing protein -
MUK76_RS03920 (807357) 807357..807446 - 90 WP_112031555.1 DUF905 family protein -
MUK76_RS03925 (807589) 807589..808044 - 456 WP_000581502.1 IrmA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13941.80 Da        Isoelectric Point: 7.3225

>T241208 WP_001513431.1 NZ_CP095083:c804451-804074 [Escherichia coli]
MNTLPDTHVREASGCPSPITIRQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T241208 NZ_LT962936:1044638-1044883 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13688.48 Da        Isoelectric Point: 5.9505

>AT241208 WP_001513429.1 NZ_CP095083:c804875-804498 [Escherichia coli]
VSDTLPGTTPPDDNHDRPWWGLPCTVTSCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Download         Length: 378 bp

>AT241208 NZ_LT962936:1044883-1045197 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9ZA48


Antitoxin

Source ID Structure
AlphaFold DB U9YYT7

References