Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 804074..804875 | Replicon | chromosome |
| Accession | NZ_CP095083 | ||
| Organism | Escherichia coli strain EC6868 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | U9ZA48 |
| Locus tag | MUK76_RS03890 | Protein ID | WP_001513431.1 |
| Coordinates | 804074..804451 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | U9YYT7 |
| Locus tag | MUK76_RS03895 | Protein ID | WP_001513429.1 |
| Coordinates | 804498..804875 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUK76_RS03865 (800206) | 800206..801189 | - | 984 | WP_001329577.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
| MUK76_RS03870 (801999) | 801999..802130 | - | 132 | Protein_761 | IS110 family transposase | - |
| MUK76_RS03875 (802512) | 802512..803354 | - | 843 | WP_001513432.1 | DUF4942 domain-containing protein | - |
| MUK76_RS03880 (803439) | 803439..803636 | - | 198 | WP_001374283.1 | DUF957 domain-containing protein | - |
| MUK76_RS03885 (803648) | 803648..804023 | - | 376 | Protein_764 | DUF5983 family protein | - |
| MUK76_RS03890 (804074) | 804074..804451 | - | 378 | WP_001513431.1 | TA system toxin CbtA family protein | Toxin |
| MUK76_RS03895 (804498) | 804498..804875 | - | 378 | WP_001513429.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MUK76_RS03900 (805038) | 805038..805259 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| MUK76_RS03905 (805328) | 805328..805804 | - | 477 | WP_001186726.1 | RadC family protein | - |
| MUK76_RS03910 (805820) | 805820..806305 | - | 486 | WP_001513428.1 | antirestriction protein | - |
| MUK76_RS03915 (806360) | 806360..807178 | - | 819 | WP_001513427.1 | DUF932 domain-containing protein | - |
| MUK76_RS03920 (807357) | 807357..807446 | - | 90 | WP_112031555.1 | DUF905 family protein | - |
| MUK76_RS03925 (807589) | 807589..808044 | - | 456 | WP_000581502.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13941.80 Da Isoelectric Point: 7.3225
>T241208 WP_001513431.1 NZ_CP095083:c804451-804074 [Escherichia coli]
MNTLPDTHVREASGCPSPITIRQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
MNTLPDTHVREASGCPSPITIRQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
Download Length: 378 bp
>T241208 NZ_LT962936:1044638-1044883 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13688.48 Da Isoelectric Point: 5.9505
>AT241208 WP_001513429.1 NZ_CP095083:c804875-804498 [Escherichia coli]
VSDTLPGTTPPDDNHDRPWWGLPCTVTSCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
VSDTLPGTTPPDDNHDRPWWGLPCTVTSCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
Download Length: 378 bp
>AT241208 NZ_LT962936:1044883-1045197 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|