Detailed information of TA system TA241203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1268758..1270010
• Replicon: chromosome
• Accession: NZ_CP095081
• Organism: Streptococcus dysgalactiae strain WJ001

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: MP619_RS06520
• Protein ID: WP_268227694.1
• Coordinates: 1268758..1269534 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: MP619_RS06525
• Protein ID: WP_268227695.1
• Coordinates: 1269534..1270010 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MP619_RS06505 (MP619_06480)	1263832..1264943	+	1112	WP_089180045.1	IS3-like element IS981 family transposase	-
MP619_RS06510 (MP619_06485)	1264954..1267968	-	3015	WP_268227693.1	DEAD/DEAH box helicase	-
MP619_RS06515 (MP619_06490)	1267965..1268774	-	810	WP_214257440.1	SAVED domain-containing protein	-
MP619_RS06520 (MP619_06495)	1268758..1269534	-	777	WP_268227694.1	type II toxin-antitoxin system toxin PezT	Toxin
MP619_RS06525 (MP619_06500)	1269534..1270010	-	477	WP_268227695.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
MP619_RS06530 (MP619_06505)	1270203..1270895	+	693	WP_268227696.1	XRE family transcriptional regulator	-
MP619_RS06535	1270898..1271032	+	135	WP_256770376.1	hypothetical protein	-
MP619_RS06540 (MP619_06510)	1271037..1272452	+	1416	WP_268227894.1	Y-family DNA polymerase	-
MP619_RS06545 (MP619_06515)	1272449..1272817	+	369	WP_268227697.1	hypothetical protein	-
MP619_RS06550 (MP619_06520)	1272804..1273103	+	300	WP_268227698.1	DUF5960 family protein	-
MP619_RS06555 (MP619_06525)	1273130..1273417	-	288	WP_039692713.1	hypothetical protein	-
MP619_RS06560 (MP619_06530)	1273462..1273857	-	396	WP_268227699.1	DUF5945 family protein	-
MP619_RS06565 (MP619_06535)	1273861..1274088	-	228	WP_014334745.1	DUF5965 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1235974..1284289	48315

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29617.68 Da
• Isoelectric Point: 7.4701

>T241203 WP_268227694.1 NZ_CP095081:c1269534-1268758 [Streptococcus dysgalactiae]
MRLEEFSKDDFELALKRTIRPLTRGKMTSVNPKAILIGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLALQE
EYTKDSVDYTKGFAGKMVEHLVDELSKQGYHLLIEGTLRTTSVPRKTAQILKSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPSQARATPKEHHDGIVEHLFDNLRELETDKLFDQIQIYQRDRRCVYYSETDKGSAADVLQECLFGKWSKVEEEMM
KVGQEQLREVGRRNEKDA

Nucleotide

• Length: 777 bp

>T241203 NZ_LT962926:1044673-1044918 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18121.40 Da
• Isoelectric Point: 4.4466

>AT241203 WP_268227695.1 NZ_CP095081:c1270010-1269534 [Streptococcus dysgalactiae]
MIGDNIKSLRKTHDLTQPEFANIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDILGEEKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETSPWILMSDDLSDLINTKIYLVQSFDEVERYNGYLDGIERMLEHAHHQVVA

Nucleotide

• Length: 477 bp

>AT241203 NZ_LT962926:1044918-1045232 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA