Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2223207..2223844 Replicon chromosome
Accession NZ_CP095075
Organism Halobacillus sp. SSHM10-5

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MUO15_RS11455 Protein ID WP_245029399.1
Coordinates 2223207..2223557 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MUO15_RS11460 Protein ID WP_245029401.1
Coordinates 2223563..2223844 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO15_RS11420 (MUO15_11420) 2218716..2219495 - 780 WP_245029391.1 RNA polymerase sigma factor SigB -
MUO15_RS11425 (MUO15_11425) 2219467..2219943 - 477 WP_245029392.1 anti-sigma B factor RsbW -
MUO15_RS11430 (MUO15_11430) 2219946..2220275 - 330 WP_245029393.1 STAS domain-containing protein -
MUO15_RS11435 (MUO15_11435) 2220340..2221350 - 1011 WP_245029394.1 PP2C family protein-serine/threonine phosphatase -
MUO15_RS11440 (MUO15_11440) 2221367..2221768 - 402 WP_245029395.1 anti-sigma regulatory factor -
MUO15_RS11445 (MUO15_11445) 2221771..2222136 - 366 WP_245029396.1 STAS domain-containing protein -
MUO15_RS11450 (MUO15_11450) 2222133..2223002 - 870 WP_245029397.1 RsbT co-antagonist protein RsbRA -
MUO15_RS11455 (MUO15_11455) 2223207..2223557 - 351 WP_245029399.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUO15_RS11460 (MUO15_11460) 2223563..2223844 - 282 WP_245029401.1 antitoxin Antitoxin
MUO15_RS11465 (MUO15_11465) 2224008..2225159 - 1152 WP_245029403.1 alanine racemase -
MUO15_RS11470 (MUO15_11470) 2225392..2226417 - 1026 WP_245029405.1 outer membrane lipoprotein carrier protein LolA -
MUO15_RS11475 (MUO15_11475) 2226471..2227988 - 1518 WP_245029407.1 NAD(P)H-hydrate dehydratase -
MUO15_RS11480 (MUO15_11480) 2228037..2228402 - 366 WP_245029409.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12916.97 Da        Isoelectric Point: 5.8431

>T241202 WP_245029399.1 NZ_CP095075:c2223557-2223207 [Halobacillus sp. SSHM10-5]
VIVKRGDVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAEKYGFERNSVILLEQI
RTIDKQRLTDKITQLDGPMMQRVNESLQISLGLIDF

Download         Length: 351 bp

>T241202 NZ_LT962924:1044653-1044898 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10827.30 Da        Isoelectric Point: 4.4652

>AT241202 WP_245029401.1 NZ_CP095075:c2223844-2223563 [Halobacillus sp. SSHM10-5]
MVLSDNMQEIVIRIPDSLLNEVDGHVQLENSDRSDFMCKATKMYLREEKQRYIRESMRRGYMEMAKINLTIASEAFQAEE
EADHTLEQLVSGV

Download         Length: 282 bp

>AT241202 NZ_LT962924:1044898-1045212 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References