Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2940187..2940824 Replicon chromosome
Accession NZ_CP095074
Organism Halobacillus sp. SSTM10-2

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MUO14_RS14785 Protein ID WP_244751412.1
Coordinates 2940474..2940824 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MUO14_RS14780 Protein ID WP_244751411.1
Coordinates 2940187..2940468 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO14_RS14760 (MUO14_14760) 2935634..2936008 + 375 WP_244751407.1 holo-ACP synthase -
MUO14_RS14765 (MUO14_14765) 2936049..2937566 + 1518 WP_244751408.1 NAD(P)H-hydrate dehydratase -
MUO14_RS14770 (MUO14_14770) 2937620..2938645 + 1026 WP_244751409.1 outer membrane lipoprotein carrier protein LolA -
MUO14_RS14775 (MUO14_14775) 2938866..2940023 + 1158 WP_244751410.1 alanine racemase -
MUO14_RS14780 (MUO14_14780) 2940187..2940468 + 282 WP_244751411.1 antitoxin Antitoxin
MUO14_RS14785 (MUO14_14785) 2940474..2940824 + 351 WP_244751412.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUO14_RS14790 (MUO14_14790) 2941035..2941904 + 870 WP_244751413.1 RsbT co-antagonist protein RsbRA -
MUO14_RS14795 (MUO14_14795) 2941901..2942266 + 366 WP_244751414.1 STAS domain-containing protein -
MUO14_RS14800 (MUO14_14800) 2942269..2942670 + 402 WP_244751415.1 anti-sigma regulatory factor -
MUO14_RS14805 (MUO14_14805) 2942687..2943697 + 1011 WP_244751416.1 PP2C family protein-serine/threonine phosphatase -
MUO14_RS14810 (MUO14_14810) 2943761..2944090 + 330 WP_244751417.1 STAS domain-containing protein -
MUO14_RS14815 (MUO14_14815) 2944093..2944569 + 477 WP_244751418.1 anti-sigma B factor RsbW -
MUO14_RS14820 (MUO14_14820) 2944541..2945320 + 780 WP_244751419.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12905.94 Da        Isoelectric Point: 7.0124

>T241201 WP_244751412.1 NZ_CP095074:2940474-2940824 [Halobacillus sp. SSTM10-2]
VIVKRGDVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAEKYGFERNSVILLEQI
RTIDKQRLTDKITQLDGSMMQRVNESLQISLGLIDF

Download         Length: 351 bp

>T241201 NZ_LT962922:1044803-1045048 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCTTTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10855.31 Da        Isoelectric Point: 4.4652

>AT241201 WP_244751411.1 NZ_CP095074:2940187-2940468 [Halobacillus sp. SSTM10-2]
MVLSDNMQEIVIRIPDSLLNEVDGHVQLENSDRSDFMCKATKMYLREEKQRYIRESMRRGYMEMARINLTIASEAFQAEE
EADHTLEQLVSGV

Download         Length: 282 bp

>AT241201 NZ_LT962922:1045048-1045362 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References