Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 4174145..4174782 Replicon chromosome
Accession NZ_CP095073
Organism Halobacillus sp. SSBR10-3

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MUN89_RS21405 Protein ID WP_244714003.1
Coordinates 4174145..4174495 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MUN89_RS21410 Protein ID WP_244710234.1
Coordinates 4174501..4174782 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUN89_RS21370 (MUN89_21370) 4169660..4170439 - 780 WP_244710222.1 RNA polymerase sigma factor SigB -
MUN89_RS21375 (MUN89_21375) 4170414..4170887 - 474 WP_244710223.1 anti-sigma B factor RsbW -
MUN89_RS21380 (MUN89_21380) 4170890..4171219 - 330 WP_244710225.1 STAS domain-containing protein -
MUN89_RS21385 (MUN89_21385) 4171282..4172292 - 1011 WP_244710227.1 PP2C family protein-serine/threonine phosphatase -
MUN89_RS21390 (MUN89_21390) 4172305..4172706 - 402 WP_244710228.1 anti-sigma regulatory factor -
MUN89_RS21395 (MUN89_21395) 4172709..4173074 - 366 WP_244710230.1 STAS domain-containing protein -
MUN89_RS21400 (MUN89_21400) 4173071..4173940 - 870 WP_244710232.1 RsbT co-antagonist protein RsbRA -
MUN89_RS21405 (MUN89_21405) 4174145..4174495 - 351 WP_244714003.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUN89_RS21410 (MUN89_21410) 4174501..4174782 - 282 WP_244710234.1 antitoxin Antitoxin
MUN89_RS21415 (MUN89_21415) 4174941..4176098 - 1158 WP_244710235.1 alanine racemase -
MUN89_RS21420 (MUN89_21420) 4176208..4177230 - 1023 WP_244710237.1 outer membrane lipoprotein carrier protein LolA -
MUN89_RS21425 (MUN89_21425) 4177281..4178795 - 1515 WP_244710239.1 NAD(P)H-hydrate dehydratase -
MUN89_RS21430 (MUN89_21430) 4178854..4179210 - 357 WP_244710241.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12919.00 Da        Isoelectric Point: 5.8353

>T241200 WP_244714003.1 NZ_CP095073:c4174495-4174145 [Halobacillus sp. SSBR10-3]
MIVKRGDVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAKYGFERNSVILLEQI
RTIDKQRLTDKITQLDDPMMQRVNEALQISLGLIDF

Download         Length: 351 bp

>T241200 NZ_LT962920:1044603-1044848 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10835.36 Da        Isoelectric Point: 4.5686

>AT241200 WP_244710234.1 NZ_CP095073:c4174782-4174501 [Halobacillus sp. SSBR10-3]
MVLSDSMQEIVIRIPDNLLNEVDGFIQLENSDRSDFMCQATKMYLREKKQRHIRETMRRGYMEMAKINLNIASEAFQAEE
EAEHTLEQLVGGV

Download         Length: 282 bp

>AT241200 NZ_LT962920:1044848-1045162 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References