241198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 3538264..3538899 Replicon chromosome
Accession NZ_CP095071
Organism Gracilibacillus sp. SSPM10-3

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MUN87_RS16520 Protein ID WP_244720658.1
Coordinates 3538549..3538899 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MUN87_RS16515 Protein ID WP_244720661.1
Coordinates 3538264..3538545 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUN87_RS16495 (MUN87_16495) 3534754..3535753 + 1000 Protein_3255 IS1380 family transposase -
MUN87_RS16500 (MUN87_16500) 3535797..3536084 + 288 WP_244741817.1 hypothetical protein -
MUN87_RS16505 (MUN87_16505) 3536099..3536269 + 171 WP_244741820.1 WYL domain-containing protein -
MUN87_RS16510 (MUN87_16510) 3536969..3538087 + 1119 WP_244741823.1 alanine racemase -
MUN87_RS16515 (MUN87_16515) 3538264..3538545 + 282 WP_244720661.1 antitoxin Antitoxin
MUN87_RS16520 (MUN87_16520) 3538549..3538899 + 351 WP_244720658.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUN87_RS16525 (MUN87_16525) 3539067..3539930 + 864 WP_244741825.1 RsbT co-antagonist protein RsbRA -
MUN87_RS16530 (MUN87_16530) 3539944..3540300 + 357 WP_244720652.1 STAS domain-containing protein -
MUN87_RS16535 (MUN87_16535) 3540303..3540704 + 402 WP_244747994.1 anti-sigma regulatory factor -
MUN87_RS16540 (MUN87_16540) 3540799..3541803 + 1005 WP_244741828.1 PP2C family protein-serine/threonine phosphatase -
MUN87_RS16545 (MUN87_16545) 3541923..3542252 + 330 WP_244741830.1 STAS domain-containing protein -
MUN87_RS16550 (MUN87_16550) 3542253..3542729 + 477 WP_244741832.1 anti-sigma B factor RsbW -
MUN87_RS16555 (MUN87_16555) 3542701..3543492 + 792 WP_244741856.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3534754..3535296 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12969.96 Da        Isoelectric Point: 5.1634

>T241198 WP_244720658.1 NZ_CP095071:3538549-3538899 [Gracilibacillus sp. SSPM10-3]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVLQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAEKYGFERNSVILLEQI
RTIDKQRLTDKITQLDSNMMERIDRGLEISLGLTDF

Download         Length: 351 bp

>T241198 NZ_LT962916:1044676-1044921 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.07 Da        Isoelectric Point: 4.4508

>AT241198 WP_244720661.1 NZ_CP095071:3538264-3538545 [Gracilibacillus sp. SSPM10-3]
MVLSEDLQEVAVRLPKNLLNEVDGLMKSEDSNLSDFICQATRTYLRETKKRHIQESMQRGYMEMAKINLNIASEAFQAEE
EAENTLERLVSGV

Download         Length: 282 bp

>AT241198 NZ_LT962916:1044921-1045235 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References