Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 20085..20665 Replicon plasmid unnamed1
Accession NZ_CP095059
Organism Hymenobacter sp. 5516J-16

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUN84_RS22550 Protein ID WP_244699196.1
Coordinates 20085..20417 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUN84_RS22555 Protein ID WP_244699199.1
Coordinates 20405..20665 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUN84_RS22520 (MUN84_22520) 15440..15832 - 393 WP_244699180.1 plasmid mobilization relaxosome protein MobC -
MUN84_RS22525 (MUN84_22525) 16454..16723 - 270 WP_244699182.1 hypothetical protein -
MUN84_RS22530 (MUN84_22530) 17233..18126 + 894 WP_244699186.1 replication initiation protein -
MUN84_RS22535 (MUN84_22535) 18131..18679 - 549 WP_244699188.1 helix-turn-helix domain-containing protein -
MUN84_RS22540 (MUN84_22540) 19218..19724 + 507 WP_244699191.1 type II toxin-antitoxin system VapC family toxin -
MUN84_RS22545 (MUN84_22545) 19811..20041 + 231 WP_244699193.1 hypothetical protein -
MUN84_RS22550 (MUN84_22550) 20085..20417 - 333 WP_244699196.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUN84_RS22555 (MUN84_22555) 20405..20665 - 261 WP_244699199.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MUN84_RS22560 (MUN84_22560) 20859..21134 - 276 WP_244699202.1 hypothetical protein -
MUN84_RS22565 (MUN84_22565) 21297..21869 + 573 WP_262920729.1 SUKH-4 family immunity protein -
MUN84_RS22570 (MUN84_22570) 22719..23174 - 456 WP_244699206.1 hypothetical protein -
MUN84_RS22575 (MUN84_22575) 23641..24894 + 1254 WP_244699209.1 hypothetical protein -
MUN84_RS22580 (MUN84_22580) 25085..25492 + 408 WP_244699212.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..26953 26953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12586.45 Da        Isoelectric Point: 8.2688

>T241196 WP_244699196.1 NZ_CP095059:c20417-20085 [Hymenobacter sp. 5516J-16]
MAVVAVQRFEVWLINLDPTQGSEINKTRPCVVLSPDEMNRYLRTVTIAALTSTRRDYPSRVDCTFQGKEGQVALDHIRSV
DKTRLVRRLGALPTTTAQEVCDRLQEMFQY

Download         Length: 333 bp

>T241196 NZ_LT962912:1044688-1044933 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9941.22 Da        Isoelectric Point: 4.8304

>AT241196 WP_244699199.1 NZ_CP095059:c20665-20405 [Hymenobacter sp. 5516J-16]
MNTRLIRVGNSQGIVLPKKLLQQYHLSGEVDLQPTPEGLLIKPVSKLRRQGWDERFQHALAQGQDPEGELLEGFSDEAFE
EKEWQW

Download         Length: 261 bp

>AT241196 NZ_LT962912:1044933-1045247 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References