Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 4145200..4145780 Replicon chromosome
Accession NZ_CP095053
Organism Hymenobacter sp. 5413J-13

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUN82_RS17360 Protein ID WP_245092500.1
Coordinates 4145200..4145532 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUN82_RS17365 Protein ID WP_245092502.1
Coordinates 4145520..4145780 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUN82_RS17345 (MUN82_17345) 4140332..4141885 + 1554 WP_245092495.1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase -
MUN82_RS17350 (MUN82_17350) 4141878..4142468 + 591 WP_245092497.1 hypothetical protein -
MUN82_RS17355 (MUN82_17355) 4142643..4144769 - 2127 WP_245092499.1 hypothetical protein -
MUN82_RS17360 (MUN82_17360) 4145200..4145532 - 333 WP_245092500.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUN82_RS17365 (MUN82_17365) 4145520..4145780 - 261 WP_245092502.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MUN82_RS17370 (MUN82_17370) 4145908..4146288 + 381 WP_245092504.1 hypothetical protein -
MUN82_RS17375 (MUN82_17375) 4146394..4149213 - 2820 WP_245092506.1 prolyl oligopeptidase family serine peptidase -
MUN82_RS17380 (MUN82_17380) 4149404..4150000 - 597 WP_245092507.1 hypothetical protein -
MUN82_RS17385 (MUN82_17385) 4150066..4150500 - 435 WP_245092510.1 secondary thiamine-phosphate synthase enzyme YjbQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12545.42 Da        Isoelectric Point: 8.7343

>T241193 WP_245092500.1 NZ_CP095053:c4145532-4145200 [Hymenobacter sp. 5413J-13]
MAVVAAQRFEVWLVNLDSTQGSEISKPRPCVVLSPDEMNRYLRTVTIAALTSTQRDYPSRVDCTFQEKEGQVALDRIRSV
DKTRLVRRLGVLPKTTAQAVCDRLQEIFQY

Download         Length: 333 bp

>T241193 NZ_LT962688:c4112719-4112282 [Methylorubrum extorquens]
ATGGTTCCGCCCCGCGCCTGGGGCGAGCGGCAATCTTTGCAACCCCACGGAATACCAGTTTTCCACATATGTTGGCCCGC
CACGCAGGCCGGATCGCGCGGGTGCGGTTGCAGAGCATCAGACGGTATTGTACGTTGTCCGTACAATGACGACCTCATAA
TCCTCAGCTACCGTAACAGAGACACCGAAGCGCTGGACGTGCACGGTGTGTGCCATCGCCGCTGGCGATCCTTTCAAGCT
GCGGCCGGGCGCAAGCTCGATATGCTGAACGCCGCCTCTGTCGTGAGCGACCTGCGCAGCCCGCCCGGCAACCGTCTGGA
GAAGCTGTCGGGTGATCGCGAGGGCCAGTGGAGCATCCGCATCAACGATCAATGGCGCATCTGCTTCCGATGGGACGGTT
CGGGGCCCGAGGATGTCGAGATTGTCGATTATCACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9804.08 Da        Isoelectric Point: 4.4297

>AT241193 WP_245092502.1 NZ_CP095053:c4145780-4145520 [Hymenobacter sp. 5413J-13]
MNTRLIRVGNSQGIVLPKKLLQQYQLAGEVDLQPTPEGLLIKPVAKPRRQGWDERFQQAIAQGQAPEGELLEGFSDEAFE
ETEWQW

Download         Length: 261 bp

>AT241193 NZ_LT962688:c4112268-4111984 [Methylorubrum extorquens]
ATGCCTCGCATTAGATCTCATCCGGGCGAGATCCTGCTCGAAGAATACCTTCGACCCCTGGAAATGAGCGCCAACGCTCT
GGCGAAGGCGATCGAGGTGCCAGCCAACCGCATCAGCGAACTTCTGCGCGGTCGCCGCGGGATGACCGCCGACACGGCCT
GCCGCCTCGGCCGGTTCTTCGGGACCACGCCGGAATTCTGGATGAGCCTCCAGACCGCCCACGATCTGTCGAGGGCCGTC
GCGGAGCACGACTATTCCACCTTGCGTGCTCTCGAAAGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References