Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 103289..103869 Replicon plasmid unnamed1
Accession NZ_CP095047
Organism Hymenobacter sp. 5116S-3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUN79_RS29000 Protein ID WP_244678448.1
Coordinates 103289..103549 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUN79_RS29005 Protein ID WP_244678449.1
Coordinates 103537..103869 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUN79_RS28980 (MUN79_28980) 100354..100854 - 501 WP_244678444.1 T9SS type A sorting domain-containing protein -
MUN79_RS28985 (MUN79_28985) 100851..102128 - 1278 WP_244678445.1 hypothetical protein -
MUN79_RS28990 (MUN79_28990) 102372..102518 + 147 WP_244678446.1 hypothetical protein -
MUN79_RS28995 (MUN79_28995) 102709..103059 - 351 WP_244678447.1 hypothetical protein -
MUN79_RS29000 (MUN79_29000) 103289..103549 + 261 WP_244678448.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
MUN79_RS29005 (MUN79_29005) 103537..103869 + 333 WP_244678449.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
MUN79_RS29010 (MUN79_29010) 103939..104415 - 477 WP_244678450.1 hypothetical protein -
MUN79_RS29015 (MUN79_29015) 104694..106667 - 1974 WP_244678451.1 T9SS type A sorting domain-containing protein -
MUN79_RS29020 (MUN79_29020) 106706..108244 - 1539 WP_244678452.1 hypothetical protein -
MUN79_RS29025 (MUN79_29025) 108291..108791 - 501 WP_262923094.1 DNA/RNA non-specific endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..137865 137865


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(6-108)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9872.15 Da        Isoelectric Point: 4.5960

>T241191 WP_244678448.1 NZ_CP095047:103289-103549 [Hymenobacter sp. 5116S-3]
MNTRLIRVGNSQGIVLPKKLLLQYHLSGEVDLQPTPEGLLITPVRKPRRQGWDEQFQRALAQGQAPEGELLEGFSDEAFE
ETEWQW

Download         Length: 261 bp

>T241191 NZ_LT962688:c2604515-2604213 [Methylorubrum extorquens]
ATGGCCCTCGAAACGCAGCCTTACGACAGCGCCGAGCACCTGAAGACGCCCGAACACATCGCGGCCTATCTCGATGCCGT
GTTGGAAGATAACGATCCCGCACTGCTCGCTCACGCGCTCGGTGTCATCGCGCGCGCCCGCGGAATGACGCAGATCGCTC
AGGACGTCGGCCGGTCGCGAGAACAACTCTACCGAACCCTGTCCGACAAAGGGAACCCGCAACTCGACACGCTCATGGGT
GTGCTGAAGTCGTTAGGATTGCGCCTCAGCGTGCATCCGGTCGACGTAGAGCGATCGGCCTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12558.46 Da        Isoelectric Point: 8.2767

>AT241191 WP_244678449.1 NZ_CP095047:103537-103869 [Hymenobacter sp. 5116S-3]
MAVVAVHRFEVWLVNLDPTQGSEINKTRPCVVLSPDEMNRYLRTVTIAALTSTQREYPSRVDCTFQGKQGQVALDHIRSV
DKTRLVRRLGVLPQATAEQVCDRLLEIFQY

Download         Length: 333 bp

>AT241191 NZ_LT962688:c2604808-2604518 [Methylorubrum extorquens]
ATGCCGACGATCCGCCGTACGAGTGTCTTTCAGACTTGGATCGACGATTTGCGCGACGTTCGCGCCGTTGCGCGCATCGC
CAAGCGCATCGACCGGTTGGCGCTCGGCAATCCGGGCGACGTCAAACCGGTCGGAGACGGTGTCAGCGAGATGCGGATCG
ATTACGGCCCGGGCTACCGGATCTACTTCACCGCCCAAGGCAAGCAGATCGTCATTTTGCTTTGCGGCGGAGACAAGAGC
TCACAGGAGCGGGACATCCGAGCTGCGAAAGCGCTCGCGAAGGAGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References