Detailed information of TA system TA241189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3831363..3832048
• Replicon: chromosome
• Accession: NZ_CP095023
• Organism: Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: MUW68_RS17995
• Protein ID: WP_003417998.1
• Coordinates: 3831638..3832048 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MUW68_RS17990
• Protein ID: WP_003912220.1
• Coordinates: 3831363..3831641 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW68_RS17970 (MUW68_17970)	3827352..3828953	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
MUW68_RS17975 (MUW68_17975)	3828970..3829674	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
MUW68_RS17980 (MUW68_17980)	3829792..3830358	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
MUW68_RS17985 (MUW68_17985)	3830420..3831307	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
MUW68_RS17990 (MUW68_17990)	3831363..3831641	+	279	WP_003912220.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUW68_RS17995 (MUW68_17995)	3831638..3832048	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW68_RS18000 (MUW68_18000)	3832081..3833817	-	1737	WP_003418002.1	cholesterol oxidase	-
MUW68_RS18005 (MUW68_18005)	3833873..3835000	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
MUW68_RS18010 (MUW68_18010)	3835020..3836609	-	1590	WP_003901630.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T241189 WP_003417998.1 NZ_CP095023:3831638-3832048 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T241189 NZ_LT962688:c530529-530203 [Methylorubrum extorquens]
ATGGCCGACGCCCTCCATACCGTCATCGAGACCGAGATTTATCTTCGGTCGGCGGAGCGCCTGATGATCGAGGCGGAGCG
GGCAGCAGTCGTGGACATCCTTGCCGCCGACCCATTCGCCGGCGATGTGATCCCCGGTACGGGCGGACTGCGCAAGGTTC
GTGTGCCTCTCAACGGGCGTGGCAAGCGTGGGGGAGCACGGGTGATCACGTGTTTTGTGAGTGCACGCGGCGTGTACCTG
CTTCTGGCCTACGCGAAGAACGAGCAAGCCAATCCGACACCGGCACAGGCGCAAGGGCTGGCGCGGTTGGTCGATACGCT
GTTTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10280.75 Da
• Isoelectric Point: 10.1819

>AT241189 WP_003912220.1 NZ_CP095023:3831363-3831641 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT241189 NZ_LT962688:c530192-529899 [Methylorubrum extorquens]
ATGGATGAGGCGACGTTCCAGGAACTGACGCGCAGCCTAGAGCAGGCGGCTGCGCATGCGCGCGGCGAGACCGTTGCTGG
ATTGCAGGTGCACGTCCCCCACGACATCGACGTGGCTGCGGTGCGAAGAGCCTCGGCTCTGTCGCAGGATGCCTTCGCCC
GCCGCATCGGCGTGGCCGTCGGGACGTTGCGGAACTGGGAGCAGCGGCGGCGACGGCCCGAGGGGCCGGCCCGCGTGCTC
CTCGCTCTTCTGGAAAAGAACCCGCGCCTCGTGGAGGAGACGCTCGGCGGTTGA

Structures

Toxin

• AlphaFold DB: G0TIR9