Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3775231..3775760 | Replicon | chromosome |
| Accession | NZ_CP095023 | ||
| Organism | Mycobacterium tuberculosis strain SGF0702019 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | MUW68_RS17735 | Protein ID | WP_003417760.1 |
| Coordinates | 3775503..3775760 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | MUW68_RS17730 | Protein ID | WP_003417757.1 |
| Coordinates | 3775231..3775506 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW68_RS17695 (MUW68_17695) | 3771804..3772598 | - | 795 | WP_003417738.1 | BBE domain-containing protein | - |
| MUW68_RS17700 (MUW68_17700) | 3772680..3773051 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| MUW68_RS17705 (MUW68_17705) | 3772949..3773167 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| MUW68_RS17710 (MUW68_17710) | 3773194..3773454 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| MUW68_RS17715 (MUW68_17715) | 3773569..3773958 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| MUW68_RS17720 (MUW68_17720) | 3773972..3774265 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| MUW68_RS17725 (MUW68_17725) | 3774262..3775107 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| MUW68_RS17730 (MUW68_17730) | 3775231..3775506 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| MUW68_RS17735 (MUW68_17735) | 3775503..3775760 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUW68_RS17740 (MUW68_17740) | 3775802..3776992 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| MUW68_RS17745 (MUW68_17745) | 3777109..3777477 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| MUW68_RS17750 (MUW68_17750) | 3777474..3778025 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| MUW68_RS17755 (MUW68_17755) | 3778032..3778613 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| MUW68_RS17760 (MUW68_17760) | 3778594..3778962 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| MUW68_RS17765 (MUW68_17765) | 3778940..3779332 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T241187 WP_003417760.1 NZ_CP095023:3775503-3775760 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T241187 NZ_LT962481:c1550065-1549775 [Pseudomonas syringae pv. syringae]
ATGACCTTTAAGCTTGAATTTCTGCCCTCGGCCTTGAAGGAGTGGGAAAAACTGGGCCATACCATCCGTGTTCAGCTCAA
GAAAAAGCTTCTCGAACGACTCGGACTACCAAGAATTCCAGGCGATGCGCTTCATGGCATGCCAGATCATTACAAAATCA
AACTGCGCAGTGCAGGATACCGACTCGTCTATCGAGTCGAGGAAGATAGGGTAGTGGTAACCGTCGTTGCGGTAGGCAAG
CGCGAGCGCGGGAATATTTATGATTCGGCCAAAGGCAGGCTTGGCCCTTGA
ATGACCTTTAAGCTTGAATTTCTGCCCTCGGCCTTGAAGGAGTGGGAAAAACTGGGCCATACCATCCGTGTTCAGCTCAA
GAAAAAGCTTCTCGAACGACTCGGACTACCAAGAATTCCAGGCGATGCGCTTCATGGCATGCCAGATCATTACAAAATCA
AACTGCGCAGTGCAGGATACCGACTCGTCTATCGAGTCGAGGAAGATAGGGTAGTGGTAACCGTCGTTGCGGTAGGCAAG
CGCGAGCGCGGGAATATTTATGATTCGGCCAAAGGCAGGCTTGGCCCTTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT241187 WP_003417757.1 NZ_CP095023:3775231-3775506 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT241187 NZ_LT962481:c1550300-1550055 [Pseudomonas syringae pv. syringae]
ATGCAAAGCATCCTTGCAGATGTCGCGGTCAGCGTCTCTGAACTCAAGAAAAATCCGTCAGCGGTCCTGAGTGGCGCTCA
TGGTTTACCTGTGGCCGTCCTTAATCACAATAAAGTCATGGGCTACATGGTCCCTGCCGAGGTGTTTGAAGCAATGATGG
AGAGGCTTGATGACCTTGATCTGGCCGAGCTGATCAAATCTCGCCAACATGAAAAGCCGGTGTCGGTAGATATAGATGAC
CTTTAA
ATGCAAAGCATCCTTGCAGATGTCGCGGTCAGCGTCTCTGAACTCAAGAAAAATCCGTCAGCGGTCCTGAGTGGCGCTCA
TGGTTTACCTGTGGCCGTCCTTAATCACAATAAAGTCATGGGCTACATGGTCCCTGCCGAGGTGTTTGAAGCAATGATGG
AGAGGCTTGATGACCTTGATCTGGCCGAGCTGATCAAATCTCGCCAACATGAAAAGCCGGTGTCGGTAGATATAGATGAC
CTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|