Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3704745..3705419 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag MUW68_RS17520 Protein ID WP_003417282.1
Coordinates 3704745..3705173 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag MUW68_RS17525 Protein ID WP_003417286.1
Coordinates 3705177..3705419 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS17495 (MUW68_17495) 3700567..3700968 - 402 WP_003417264.1 cytidine deaminase -
MUW68_RS17500 (MUW68_17500) 3701205..3701543 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
MUW68_RS17505 (MUW68_17505) 3701540..3701974 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
MUW68_RS17510 (MUW68_17510) 3702103..3703875 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
MUW68_RS17515 (MUW68_17515) 3703875..3704666 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
MUW68_RS17520 (MUW68_17520) 3704745..3705173 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS17525 (MUW68_17525) 3705177..3705419 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
MUW68_RS17530 (MUW68_17530) 3705541..3706155 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
MUW68_RS17535 (MUW68_17535) 3706152..3706817 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
MUW68_RS17540 (MUW68_17540) 3706818..3707351 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
MUW68_RS17545 (MUW68_17545) 3707348..3707722 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
MUW68_RS17550 (MUW68_17550) 3707819..3708955 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T241186 WP_003417282.1 NZ_CP095023:c3705173-3704745 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T241186 NZ_LT962480:4529171-4529461 [Pseudomonas syringae pv. syringae]
ATGACCTTTAAGCTTGAATTTCTGCCCTCGGCCTTGAAGGAGTGGGAAAAACTGGGCCATACCATCCGTGTTCAGCTCAA
GAAAAAGCTTCTCGAACGACTCGGACTACCAAGAATTCCAGGCGATGCGCTTCATGGCATGCCAGATCATTACAAAATCA
AACTGCGCAGTGCAGGATACCGACTCGTCTATCGAGTCGAGGAAGATAGGGTAGTGGTAACCGTCGTTGCGGTAGGCAAG
CGCGAGCGCGGGAATATTTATGATTCGGCCAAAGGCAGGCTTGGCCCTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT241186 WP_003417286.1 NZ_CP095023:c3705419-3705177 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT241186 NZ_LT962480:4528936-4529181 [Pseudomonas syringae pv. syringae]
ATGCAAAGCATCCTTGCAGATGTCGCGGTCAGCGTCTCTGAACTCAAGAAAAATCCGTCAGCGGTCCTGAGTGGCGCTCA
TGGTTTACCTGTGGCCGTCCTTAATCACAATAAAGTCATGGGCTACATGGTCCCTGCCGAGGTGTTTGAAGCAATGATGG
AGAGGCTTGATGACCTTGATCTGGCCGAGCTGATCAAATCTCGCCAACATGAAAAGCCGGTGTCGGTAGATATAGATGAC
CTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References