Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3174303..3174990 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag MUW68_RS15130 Protein ID WP_003414624.1
Coordinates 3174547..3174990 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag MUW68_RS15125 Protein ID WP_003414620.1
Coordinates 3174303..3174560 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS15105 (MUW68_15105) 3169623..3170477 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
MUW68_RS15110 (MUW68_15110) 3170533..3171696 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MUW68_RS15115 (MUW68_15115) 3171713..3172927 - 1215 WP_003414610.1 zinc metalloprotease Rip -
MUW68_RS15120 (MUW68_15120) 3172935..3174176 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
MUW68_RS15125 (MUW68_15125) 3174303..3174560 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
MUW68_RS15130 (MUW68_15130) 3174547..3174990 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS15135 (MUW68_15135) 3175070..3175732 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
MUW68_RS15140 (MUW68_15140) 3175828..3176019 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
MUW68_RS15145 (MUW68_15145) 3176351..3178099 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
MUW68_RS15150 (MUW68_15150) 3178195..3178776 + 582 WP_003414644.1 fasciclin domain-containing protein -
MUW68_RS15155 (MUW68_15155) 3178876..3179142 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T241184 WP_003414624.1 NZ_CP095023:3174547-3174990 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T241184 NZ_LT960614:c5214190-5213867 [Hartmannibacter diazotrophicus]
ATGAGGCGAGGAGACCTCGTAACAGTCGCGATCTCCGGAGATTTCGGCAAACCAAGACCGGCTTTGATCGTCCAATCGGA
CCAATTCGAGGCCTCCGCTACGGTCACGGTTCTCTTGCTCTCCGGCACGCTGATTGACGCGCCGCTCATCCGTATCCGCG
TAGACCCGACACCTGAAAATGGCCTCAACAAACCCTCTCAAATCATGATCGACAAGATCATGACTGTCAGGCGGGAAAAA
CTGTCCGCGCCCTTCGGTCGTCTCGACAATGACCTCTTGGTGGCCGTCAATCGATCTCTGGCGCTCTTCTTAGGCTTCGG
CTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT241184 WP_003414620.1 NZ_CP095023:3174303-3174560 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT241184 NZ_LT960614:c5214408-5214187 [Hartmannibacter diazotrophicus]
ATGCCGTCTTCCGTCAATGAGCGGGTCGAACGGCGCCGGCAAGCTCTGAGAGCCGCCGGCCTGCGCCCGATCCAGATCTG
GGTTCCCGACAACAGGCGTCCGGGCTTTGCCGACGAATGCCGCAGGCAGGCCCTGCTTGCCGCCCAATCAGACGCGGCCG
ATGCGGAACTGACGGACATTCTCGATACGGCTCTCGCGGAACTGGCTGAGCCAGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References