Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 3168702..3169250 | Replicon | chromosome |
| Accession | NZ_CP095023 | ||
| Organism | Mycobacterium tuberculosis strain SGF0702019 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TFG5 |
| Locus tag | MUW68_RS15100 | Protein ID | WP_003414602.1 |
| Coordinates | 3168987..3169250 (+) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | O33347 |
| Locus tag | MUW68_RS15095 | Protein ID | WP_003414599.1 |
| Coordinates | 3168702..3168983 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW68_RS15070 (MUW68_15070) | 3164326..3165183 | - | 858 | WP_003899513.1 | type I methionyl aminopeptidase | - |
| MUW68_RS15075 (MUW68_15075) | 3165225..3165809 | - | 585 | WP_003414585.1 | DUF1707 domain-containing protein | - |
| MUW68_RS15080 (MUW68_15080) | 3165912..3166160 | + | 249 | WP_003913411.1 | antitoxin VapB23 | - |
| MUW68_RS15085 (MUW68_15085) | 3166157..3166537 | + | 381 | WP_003414592.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUW68_RS15090 (MUW68_15090) | 3166619..3168430 | - | 1812 | WP_003414596.1 | penicillin-binding protein | - |
| MUW68_RS15095 (MUW68_15095) | 3168702..3168983 | + | 282 | WP_003414599.1 | type II toxin-antitoxin system antitoxin RelF | Antitoxin |
| MUW68_RS15100 (MUW68_15100) | 3168987..3169250 | + | 264 | WP_003414602.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MUW68_RS15105 (MUW68_15105) | 3169623..3170477 | - | 855 | WP_003899516.1 | GNAT family N-acetyltransferase | - |
| MUW68_RS15110 (MUW68_15110) | 3170533..3171696 | - | 1164 | WP_003899517.1 | flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase | - |
| MUW68_RS15115 (MUW68_15115) | 3171713..3172927 | - | 1215 | WP_003414610.1 | zinc metalloprotease Rip | - |
| MUW68_RS15120 (MUW68_15120) | 3172935..3174176 | - | 1242 | WP_003414613.1 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10204.82 Da Isoelectric Point: 11.5078
>T241183 WP_003414602.1 NZ_CP095023:3168987-3169250 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR
Download Length: 264 bp
>T241183 NZ_LT960614:4117839-4118420 [Hartmannibacter diazotrophicus]
ATGAACGCCCACGACACACCGGAAAAAGCCCGGATTGCCGGCATTCTCGACTTCATTCAGGCGGCCGAAAACCTCAAGAA
CACGCTGCGCAGCGGAACGACCTCGAATGGGCGGGCCGAAAGCACCGCCGAGCATAGCTGGCGCCTGTGCCTGCTGGTGC
TGATGTTCGACCGCGACCTTGGCGACTGCGACCGGCTGAAGCTTCTGAAGCTGTGCATCGTCCACGATCTCGGCGAGGCG
ATTTCCGGCGATGTGCCCCCCATCCTTCAAGTTGAAGGCGACGGCAGGGCCGAACGCGAGCGCGCCGACCTCGAAACGCT
CTGCGCGCCGCTGCCGCAGGATCTGAGGGACGATATTCTGGCGCTCTGGGACGACTACAACACGGCGTCCTCGCCCGAAG
CCGTGCTCGCCAAGGGCTTCGACAAGTTGGAGACCATGCTGCAGCACAACGTCGGCAAGAACCCGGCCGACTTCGACTAC
GAATTCAACCTCGGCTATGGCGTGAAGCAGACCGACGCCCATCCGCTGCTGCGGGCCATCCGCACGCTCGTGGACGAGGA
AACGCGTCGTCGGGCTGGCTAG
ATGAACGCCCACGACACACCGGAAAAAGCCCGGATTGCCGGCATTCTCGACTTCATTCAGGCGGCCGAAAACCTCAAGAA
CACGCTGCGCAGCGGAACGACCTCGAATGGGCGGGCCGAAAGCACCGCCGAGCATAGCTGGCGCCTGTGCCTGCTGGTGC
TGATGTTCGACCGCGACCTTGGCGACTGCGACCGGCTGAAGCTTCTGAAGCTGTGCATCGTCCACGATCTCGGCGAGGCG
ATTTCCGGCGATGTGCCCCCCATCCTTCAAGTTGAAGGCGACGGCAGGGCCGAACGCGAGCGCGCCGACCTCGAAACGCT
CTGCGCGCCGCTGCCGCAGGATCTGAGGGACGATATTCTGGCGCTCTGGGACGACTACAACACGGCGTCCTCGCCCGAAG
CCGTGCTCGCCAAGGGCTTCGACAAGTTGGAGACCATGCTGCAGCACAACGTCGGCAAGAACCCGGCCGACTTCGACTAC
GAATTCAACCTCGGCTATGGCGTGAAGCAGACCGACGCCCATCCGCTGCTGCGGGCCATCCGCACGCTCGTGGACGAGGA
AACGCGTCGTCGGGCTGGCTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10183.40 Da Isoelectric Point: 4.3440
>AT241183 WP_003414599.1 NZ_CP095023:3168702-3168983 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH
Download Length: 282 bp
>AT241183 NZ_LT960614:4117178-4117750 [Hartmannibacter diazotrophicus]
ATGACTACCCTGCCGCTCTATCCCAAGCCTCTCGGCTCCGCCCTTCGCCGCTGGCGCACGCTCAACCGCGTCAAGCAGGC
GGCACTGGCCGAAACGCTCGGCGTTTCCCAGACGACGGTCTGCCGCTGGGAAAGCGGCGCCGTCATGCCATCCCCGCAGC
AGGTCCGCCATCTCTCCAAGCTGTTGACCGCGCGCCCCGAGGCCGCAGCCGACAAGGCGCTACTCGACCTCGTCGCCATG
GCCCATGAGCCGGTTCATCTCGTCTGCGACCTCACCCACCGGCTGCTGGCCGCCTCGCCGGCGCGCATGGCCACCTGGCG
GATTCCACTGGCCGATTTGCTCGGGGTGTCGCTGTGGCGCTTTGCCTCCGAGGGCATTCGAGCCGGCGAGACGCGACTGG
AAGAGGCGGGCTGGTACAAGCCGGTCGCCCCGGCGCTGACCATCATGACCGAACGGGCGGAGTTTCCCGAACTCACGATC
CGCGCGGGAGAGATTCGCCTCGCACGCATCCCTCTCTCCGATGGCAGCTACGCCCGGCTCGTCCGAGACGGCGCCCGCAT
CGGCCCTGAATAA
ATGACTACCCTGCCGCTCTATCCCAAGCCTCTCGGCTCCGCCCTTCGCCGCTGGCGCACGCTCAACCGCGTCAAGCAGGC
GGCACTGGCCGAAACGCTCGGCGTTTCCCAGACGACGGTCTGCCGCTGGGAAAGCGGCGCCGTCATGCCATCCCCGCAGC
AGGTCCGCCATCTCTCCAAGCTGTTGACCGCGCGCCCCGAGGCCGCAGCCGACAAGGCGCTACTCGACCTCGTCGCCATG
GCCCATGAGCCGGTTCATCTCGTCTGCGACCTCACCCACCGGCTGCTGGCCGCCTCGCCGGCGCGCATGGCCACCTGGCG
GATTCCACTGGCCGATTTGCTCGGGGTGTCGCTGTGGCGCTTTGCCTCCGAGGGCATTCGAGCCGGCGAGACGCGACTGG
AAGAGGCGGGCTGGTACAAGCCGGTCGCCCCGGCGCTGACCATCATGACCGAACGGGCGGAGTTTCCCGAACTCACGATC
CGCGCGGGAGAGATTCGCCTCGCACGCATCCCTCTCTCCGATGGCAGCTACGCCCGGCTCGTCCGAGACGGCGCCCGCAT
CGGCCCTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 3G5O |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 3G5O | |
| AlphaFold DB | A0A7U4BWP8 |