Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN_Sll0205-like-Phd |
| Location | 3127785..3128389 | Replicon | chromosome |
| Accession | NZ_CP095023 | ||
| Organism | Mycobacterium tuberculosis strain SGF0702019 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P71623 |
| Locus tag | MUW68_RS14905 | Protein ID | WP_003414492.1 |
| Coordinates | 3127785..3128177 (-) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A829CBY8 |
| Locus tag | MUW68_RS14910 | Protein ID | WP_003414495.1 |
| Coordinates | 3128174..3128389 (-) | Length | 72 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW68_RS14875 (MUW68_14875) | 3122935..3123723 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| MUW68_RS14880 (MUW68_14880) | 3124057..3124602 | - | 546 | WP_014584866.1 | DUF1802 family protein | - |
| MUW68_RS14885 (MUW68_14885) | 3124874..3125758 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| MUW68_RS14890 (MUW68_14890) | 3125761..3126648 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | - |
| MUW68_RS14895 (MUW68_14895) | 3126953..3127498 | - | 546 | WP_003899500.1 | DUF1802 family protein | - |
| MUW68_RS14900 (MUW68_14900) | 3127495..3127764 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| MUW68_RS14905 (MUW68_14905) | 3127785..3128177 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MUW68_RS14910 (MUW68_14910) | 3128174..3128389 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUW68_RS14915 (MUW68_14915) | 3128436..3129185 | + | 750 | WP_003902358.1 | enoyl-CoA hydratase | - |
| MUW68_RS14920 (MUW68_14920) | 3129264..3130346 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
| MUW68_RS14925 (MUW68_14925) | 3130339..3131649 | - | 1311 | WP_003414501.1 | ABC transporter substrate-binding protein | - |
| MUW68_RS14930 (MUW68_14930) | 3131652..3132479 | - | 828 | WP_003414504.1 | carbohydrate ABC transporter permease | - |
| MUW68_RS14935 (MUW68_14935) | 3132476..3133387 | - | 912 | WP_003414505.1 | sugar ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14610.74 Da Isoelectric Point: 6.7594
>T241182 WP_003414492.1 NZ_CP095023:c3128177-3127785 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
Download Length: 393 bp
>T241182 NZ_LT960613:c67937-67623 [Vibrio tapetis subsp. tapetis]
ATGCACGTAATAAGTAAAAGACCATTTAATGATGCTAAGAAAAATTTTCCTACGTGTGCCGAAGCTTTGGATGCAGCATA
TAAAGTATTGCGTATAAGTCGAGCTAAAACACCGGAGGAATTAAAAGCTTTGTTTCCATCATTAGATAATTGTAAGTACA
GGGATAAGTTGTATGTTATTGACATTGGCGGTAACAAATTGCGATTGATGGCTTACATTGAATTTACGCAAGGGCGATTT
TACGTAAAGCATATTGTTACTCATGCGGAGTATGACAAGATAATTAAATCTTATCGAAGTGAGAAGAAAAAGTAG
ATGCACGTAATAAGTAAAAGACCATTTAATGATGCTAAGAAAAATTTTCCTACGTGTGCCGAAGCTTTGGATGCAGCATA
TAAAGTATTGCGTATAAGTCGAGCTAAAACACCGGAGGAATTAAAAGCTTTGTTTCCATCATTAGATAATTGTAAGTACA
GGGATAAGTTGTATGTTATTGACATTGGCGGTAACAAATTGCGATTGATGGCTTACATTGAATTTACGCAAGGGCGATTT
TACGTAAAGCATATTGTTACTCATGCGGAGTATGACAAGATAATTAAATCTTATCGAAGTGAGAAGAAAAAGTAG
Antitoxin
Download Length: 72 a.a. Molecular weight: 7511.55 Da Isoelectric Point: 4.9732
>AT241182 WP_003414495.1 NZ_CP095023:c3128389-3128174 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS
Download Length: 216 bp
>AT241182 NZ_LT960613:c67614-67198 [Vibrio tapetis subsp. tapetis]
ATGAATATTACACGAATGAAAGAGTTTTCTAACCAAATGATTGAAGTTATGCCTTGGATTAATGGTATCTCTACTTCTGA
TGAATACGACCAACTCATCGAGTTAATGGATGAGTTGGTCGAAGACTACGAAGGAAATCAAGTGCTTATTGACCTTTTAT
TTCCCGTTATCGAAAGATATGAATCTGAATCTGAAGAGTTCAATGAATTCAACCGTGTTGTTGGTGAGTTAGAGCCTGGG
TTAGCAATGCTCAGAGTGATCATTGATCAAAATGAAATGACTCTATCAGATTTTAAAGATGAAATTGGAGCAAAATCTAC
AGTATCAATGATTCTGAGTGGTTCACGTTCTTTGACTCTCCGACATATTAAATCCTTGTCGGAACGCTTTAATATTCCAG
CCTATATGTTCATCTAG
ATGAATATTACACGAATGAAAGAGTTTTCTAACCAAATGATTGAAGTTATGCCTTGGATTAATGGTATCTCTACTTCTGA
TGAATACGACCAACTCATCGAGTTAATGGATGAGTTGGTCGAAGACTACGAAGGAAATCAAGTGCTTATTGACCTTTTAT
TTCCCGTTATCGAAAGATATGAATCTGAATCTGAAGAGTTCAATGAATTCAACCGTGTTGTTGGTGAGTTAGAGCCTGGG
TTAGCAATGCTCAGAGTGATCATTGATCAAAATGAAATGACTCTATCAGATTTTAAAGATGAAATTGGAGCAAAATCTAC
AGTATCAATGATTCTGAGTGGTTCACGTTCTTTGACTCTCCGACATATTAAATCCTTGTCGGAACGCTTTAATATTCCAG
CCTATATGTTCATCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BWM8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CBY8 |