241181

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 3124874..3126648 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name abiEi Uniprot ID P71626
Locus tag MUW68_RS14885 Protein ID WP_003414409.1
Coordinates 3124874..3125758 (-) Length 295 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID P71625
Locus tag MUW68_RS14890 Protein ID WP_003414414.1
Coordinates 3125761..3126648 (-) Length 296 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS14865 (MUW68_14865) 3120129..3120503 - 375 WP_003414296.1 type III-A CRISPR-associated protein Csm2 -
MUW68_RS14870 (MUW68_14870) 3120500..3122938 - 2439 WP_003900580.1 type III-A CRISPR-associated protein Cas10/Csm1 -
MUW68_RS14875 (MUW68_14875) 3122935..3123723 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
MUW68_RS14880 (MUW68_14880) 3124057..3124602 - 546 WP_014584866.1 DUF1802 family protein -
MUW68_RS14885 (MUW68_14885) 3124874..3125758 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MUW68_RS14890 (MUW68_14890) 3125761..3126648 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
MUW68_RS14895 (MUW68_14895) 3126953..3127498 - 546 WP_003899500.1 DUF1802 family protein -
MUW68_RS14900 (MUW68_14900) 3127495..3127764 - 270 WP_003414489.1 DUF2277 family protein -
MUW68_RS14905 (MUW68_14905) 3127785..3128177 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin -
MUW68_RS14910 (MUW68_14910) 3128174..3128389 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MUW68_RS14915 (MUW68_14915) 3128436..3129185 + 750 WP_003902358.1 enoyl-CoA hydratase -
MUW68_RS14920 (MUW68_14920) 3129264..3130346 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 33056.72 Da        Isoelectric Point: 7.1520

>T241181 WP_003414409.1 NZ_CP095023:c3125758-3124874 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS

Download         Length: 885 bp

>T241181 NZ_LT960613:49518-50459 [Vibrio tapetis subsp. tapetis]
ATGAAAAAACTAAAACAACAATTCCTTGAGGTTTCCGATGCTTTAGCGCTAGGAAACCCAGCCATTATTGAAAAAGATTA
CTGGGTTGTTGCTCTGCTTGCTGAGCTAGAAAAACTTACCTTTGAAACTCACCAATTGGTTTTTGCAGGTGGTACGGCAT
TAGCCAAATCTAATGTCAAAATCCTACGGATGTCAGAAGACGTTGATATTAAACTGATCCCAAGTAAAGAGTTTGATGCG
TTGAGTCGTGGTAAAAAGAAAACCGCACGTAAAATGCTTATCGAGCAAATAGAGCAGGTGATTGCGCGATCTCAGCAATT
TACAGTTGAAAGCCGACTTGTTCGTGATGAATACCGTTATGTGGAGTATGAACTTAAATATCCTCAACAATTCAACCAAG
CTCCATGCTTGCGACCAATCATCAAATTAGAGCTGATGGAAACTATTCCGCTTCTAGAAGTAGAAGACCGAGGAATTCAA
TCGTTAGTTGCAGAGCTTTATAAGCAACCACAAGAGGTCAGCGCATTCGCTTGTGTTTCTGTTTACGCAACATTAGTGGA
GAAAGTACTTTCTATGTTACGTCGTACTATGTTGGTTAAGCGTGACACCGAACGTAAAGATGATGTCACGTTGGTCCGTC
ATATCTACGACGTTCATTGCATTGATACAGCGCAGACGCTAGATATTGAGTCACTAACCTCATTATTTCTCACAGTATTG
AAAGAAGATATCGACCGCTTTGGTAACCAGCATGCTGAGTTTGTCGCTGCCCCTATTAAGGAGCTACGCCTTGGCTTACA
AGAGCTAGAAGACAACCCGATTTTCCGCCAACGCTTTCAAGACTTTGTTACGCCAATGGTGTTTAACACCGAACCCCATG
ATTTTGATACCTGCTTTGCCTCATTTAAACGCATCGCTGAATCATTGATTAAAACAATTTGA

Antitoxin


Download         Length: 296 a.a.        Molecular weight: 32315.19 Da        Isoelectric Point: 9.4723

>AT241181 WP_003414414.1 NZ_CP095023:c3126648-3125761 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Download         Length: 888 bp

>AT241181 NZ_LT960613:49111-49515 [Vibrio tapetis subsp. tapetis]
ATGACTGCGGCAGATCGTATTTATCAGAATATAAAGCGTTCAAGACGCTATGTCTTTGAACGCAAAGACTTTGATGGGTT
TGCCAGTTATGATCAAGTAGGTAGAGCATTGAGGCAATTAGTAAAGCAAGGTGAACTAATGAAGCTTGGCTATGGTTTGT
ATACCAAAGCAAGGGTTAATAGCCTTACAGGAAGACCCATGCCTACCAACCCTGGTGGTAGCGATGCCCTTATCCGGGAA
ATATTAAAAATGAAGGGCGTTGACTTTGAGATGGATAGTTTGTCTCTACAGAGCTTTTCAGGTGAAAGCACACAAGTACC
ATCATCCGTTCATTATTCATGGAATCCTAAGCAGTTTAATCGCAAGCTGGTAGTAGGTAATCGAGTACTGAATTCTCCGA
GTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6Y56

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBU9

References