Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 3107587..3108157 | Replicon | chromosome |
| Accession | NZ_CP095023 | ||
| Organism | Mycobacterium tuberculosis strain SGF0702019 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | P71650 |
| Locus tag | MUW68_RS14780 | Protein ID | WP_003414166.1 |
| Coordinates | 3107587..3107943 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL61 |
| Locus tag | MUW68_RS14785 | Protein ID | WP_003901465.1 |
| Coordinates | 3107927..3108157 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW68_RS14755 (MUW68_14755) | 3103037..3104725 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
| MUW68_RS14760 (MUW68_14760) | 3104729..3105055 | - | 327 | WP_003414157.1 | hypothetical protein | - |
| MUW68_RS14765 (MUW68_14765) | 3105228..3105815 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
| MUW68_RS14770 (MUW68_14770) | 3105972..3107120 | + | 1149 | Protein_2918 | CocE/NonD family hydrolase | - |
| MUW68_RS14775 (MUW68_14775) | 3107141..3107485 | + | 345 | WP_014585334.1 | CocE/NonD family hydrolase C-terminal non-catalytic domain-containing protein | - |
| MUW68_RS14780 (MUW68_14780) | 3107587..3107943 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
| MUW68_RS14785 (MUW68_14785) | 3107927..3108157 | - | 231 | WP_003901465.1 | type II toxin-antitoxin system antitoxin MazE9 | Antitoxin |
| MUW68_RS14790 (MUW68_14790) | 3108200..3109243 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
| MUW68_RS14795 (MUW68_14795) | 3109242..3109709 | + | 468 | WP_003414177.1 | DUF1778 domain-containing protein | - |
| MUW68_RS14800 (MUW68_14800) | 3109885..3110139 | - | 255 | WP_003917684.1 | hypothetical protein | - |
| MUW68_RS14805 (MUW68_14805) | 3110287..3110691 | + | 405 | WP_003414181.1 | hypothetical protein | - |
| MUW68_RS14810 (MUW68_14810) | 3110688..3110879 | + | 192 | WP_003414184.1 | hypothetical protein | - |
| MUW68_RS14815 (MUW68_14815) | 3111096..3111356 | + | 261 | Protein_2927 | transposase | - |
| MUW68_RS14820 (MUW68_14820) | 3112466..3112723 | + | 258 | WP_003899489.1 | hypothetical protein | - |
| MUW68_RS14825 (MUW68_14825) | 3112828..3113139 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T241180 WP_003414166.1 NZ_CP095023:c3107943-3107587 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T241180 NZ_CP095023:c3107943-3107587 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT241180 WP_003901465.1 NZ_CP095023:c3108157-3107927 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT241180 NZ_CP095023:c3108157-3107927 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|