Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3067588..3068267 | Replicon | chromosome |
| Accession | NZ_CP095023 | ||
| Organism | Mycobacterium tuberculosis strain SGF0702019 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | MUW68_RS14545 | Protein ID | WP_003414059.1 |
| Coordinates | 3067588..3068004 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | MUW68_RS14550 | Protein ID | WP_003414061.1 |
| Coordinates | 3068001..3068267 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW68_RS14520 (MUW68_14520) | 3063640..3064542 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| MUW68_RS14525 (MUW68_14525) | 3064611..3065363 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| MUW68_RS14535 (MUW68_14535) | 3065607..3065882 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| MUW68_RS14540 (MUW68_14540) | 3065879..3067501 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| MUW68_RS14545 (MUW68_14545) | 3067588..3068004 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| MUW68_RS14550 (MUW68_14550) | 3068001..3068267 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MUW68_RS14555 (MUW68_14555) | 3068293..3068688 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| MUW68_RS14560 (MUW68_14560) | 3068685..3068954 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| MUW68_RS14565 (MUW68_14565) | 3068964..3070058 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| MUW68_RS14570 (MUW68_14570) | 3070055..3070474 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| MUW68_RS14575 (MUW68_14575) | 3070473..3070547 | + | 75 | Protein_2879 | hypothetical protein | - |
| MUW68_RS14580 (MUW68_14580) | 3070548..3071027 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| MUW68_RS14585 (MUW68_14585) | 3071098..3071898 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| MUW68_RS14590 (MUW68_14590) | 3072054..3072791 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T241178 WP_003414059.1 NZ_CP095023:c3068004-3067588 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T241178 NZ_LT960612:1238050-1238580 [Vibrio tapetis subsp. tapetis]
GTGAGTTATTCCAAAGCTTTTAAAGAATTGGATAAATCACAACACGATAGAGCATCATTTGACTGCGGTGAAAAAGAGTT
AAATGGTTTTATCCAAACTCAAGCCGCTAAACATATGCAAGCAGGTATTAGCCGAACCATGGTTTTACCTGCTTCAGTGC
CATTACCAAATCAAAAATATCCAATTTGTTCATTTTATAGTATCGCGCCAAGCTCAATTAGCCGTGATACGTTGCCAAAA
GCAATGGCTAAAAAATTACCACGCTATCCAATTCCTGTTTTTCTTTTAGCTCAGCTTGCAGTTCATAAGGAATTTCATGG
CAGTGGGTTAGGTAAAGTTAGCTTAATCAAAGCCCTAGAATATCTTTGGGAAATTAACTCTCACATGAGAGCTTATGCCA
TTGTTGTTGATTGTTTTACCGAACAAGCAGAGTCATTTTACGCAAAATATGGTTTCGAGGTTCTTTGCGAAATCAATGGT
CGTGCAAGAATGTTCATTCCAATGAAAACAGTCGGTCAGTTATTCACTTAG
GTGAGTTATTCCAAAGCTTTTAAAGAATTGGATAAATCACAACACGATAGAGCATCATTTGACTGCGGTGAAAAAGAGTT
AAATGGTTTTATCCAAACTCAAGCCGCTAAACATATGCAAGCAGGTATTAGCCGAACCATGGTTTTACCTGCTTCAGTGC
CATTACCAAATCAAAAATATCCAATTTGTTCATTTTATAGTATCGCGCCAAGCTCAATTAGCCGTGATACGTTGCCAAAA
GCAATGGCTAAAAAATTACCACGCTATCCAATTCCTGTTTTTCTTTTAGCTCAGCTTGCAGTTCATAAGGAATTTCATGG
CAGTGGGTTAGGTAAAGTTAGCTTAATCAAAGCCCTAGAATATCTTTGGGAAATTAACTCTCACATGAGAGCTTATGCCA
TTGTTGTTGATTGTTTTACCGAACAAGCAGAGTCATTTTACGCAAAATATGGTTTCGAGGTTCTTTGCGAAATCAATGGT
CGTGCAAGAATGTTCATTCCAATGAAAACAGTCGGTCAGTTATTCACTTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT241178 WP_003414061.1 NZ_CP095023:c3068267-3068001 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT241178 NZ_LT960612:1237784-1238053 [Vibrio tapetis subsp. tapetis]
ATGGCGACTGCAAGACTTGATATCCGTTTGGATGAAGAAATCAAAGCTAAGGCTGAGAAAGCTTCAGCTTTACTTGGTTT
AAAAAGCTTAACTGAATACGTTGTTCGTTTAATGGACGAAGATTCAACTCAGGTGATTTCAGAACATGAAAGCATCACTG
TTGAAGCAAATGTATTTGACCAATTCATGATTGCTTGTGACGAGGCTAAGGCTCCGAATAAAGCATTACTTGAAGCGGCT
GCATTTACTAAAAGTGGTGAGTTTAAGTGA
ATGGCGACTGCAAGACTTGATATCCGTTTGGATGAAGAAATCAAAGCTAAGGCTGAGAAAGCTTCAGCTTTACTTGGTTT
AAAAAGCTTAACTGAATACGTTGTTCGTTTAATGGACGAAGATTCAACTCAGGTGATTTCAGAACATGAAAGCATCACTG
TTGAAGCAAATGTATTTGACCAATTCATGATTGCTTGTGACGAGGCTAAGGCTCCGAATAAAGCATTACTTGAAGCGGCT
GCATTTACTAAAAGTGGTGAGTTTAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|