Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2928596..2929310 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag MUW68_RS13720 Protein ID WP_003413460.1
Coordinates 2928870..2929310 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag MUW68_RS13715 Protein ID WP_003413456.1
Coordinates 2928596..2928883 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS13680 (MUW68_13680) 2924019..2924264 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MUW68_RS13685 (MUW68_13685) 2924261..2924665 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
MUW68_RS13690 (MUW68_13690) 2924882..2925502 + 621 WP_003413441.1 DUF4178 domain-containing protein -
MUW68_RS13695 (MUW68_13695) 2925513..2926007 + 495 WP_003413444.1 DUF2617 family protein -
MUW68_RS13700 (MUW68_13700) 2926004..2926434 + 431 Protein_2709 DUF4247 domain-containing protein -
MUW68_RS13705 (MUW68_13705) 2926459..2926917 + 459 WP_003413451.1 DUF350 domain-containing protein -
MUW68_RS13710 (MUW68_13710) 2926914..2928485 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
MUW68_RS13715 (MUW68_13715) 2928596..2928883 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
MUW68_RS13720 (MUW68_13720) 2928870..2929310 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS13725 (MUW68_13725) 2929331..2930086 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
MUW68_RS13730 (MUW68_13730) 2930219..2930815 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
MUW68_RS13735 (MUW68_13735) 2930823..2931668 - 846 WP_003413466.1 acyl-CoA thioesterase II -
MUW68_RS13740 (MUW68_13740) 2931697..2932596 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
MUW68_RS13745 (MUW68_13745) 2932724..2933398 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T241176 WP_003413460.1 NZ_CP095023:2928870-2929310 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T241176 NZ_LT960612:c22536-22135 [Vibrio tapetis subsp. tapetis]
ATGCTCGATACGTGTATTTGTTCATTCATTATGAGAGAACAACCTATCGCGGTATTGAAAATGTTACAGGATGTGGTTGG
TAAACAACACCGAATCGTCATTTCCGCTATCACCTACCAAGAAATGCAGTACGGGTTATTAGGTAAAAAAGCTTCCCCTA
AACATGCTGTGCTTGTTGCCGAATTTCTAAAGCGTGTTGATGAAATATTGCCTTGGGATAAAGTGGCAGTTGATGCAACA
ACCGAAGTAAAGCGCAGCCTAATGGCAAAAGGTACACCGATTGGTAATAACGATACGGCTATTGCTGGTCATGCCATCGC
GACAGGTTGTGTGTTAGTCACCAATAACACGAGAGAGTTCCAGCGTGTCGAAGGGTTGAAACTGGAAGATTGGGTTCATT
AG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT241176 WP_003413456.1 NZ_CP095023:2928596-2928883 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT241176 NZ_LT960612:c22783-22550 [Vibrio tapetis subsp. tapetis]
ATGAGAACAGTGTCTATTTTCAAAAATGGTAAGAATCAAGCGGTTCGTCTACCAAAAGATTTTGAGTTTGATGGAGTTAA
TGAGCTTGAAATTCACAAGGAGGGGGATGTGATCACCTTGCGCCCAGCTCGTCCAGACTGGTTGTCATTTGGTGAGCAAG
AAAAGCCCGATGAGGATTTCATGGCTAACCGTGAAGATGTGATTAAAGATGAAGGGCGATTCAATTTTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References