Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2852796..2853436 | Replicon | chromosome |
| Accession | NZ_CP095023 | ||
| Organism | Mycobacterium tuberculosis strain SGF0702019 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ08 |
| Locus tag | MUW68_RS13350 | Protein ID | WP_003412970.1 |
| Coordinates | 2852796..2853215 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TQ09 |
| Locus tag | MUW68_RS13355 | Protein ID | WP_003412975.1 |
| Coordinates | 2853212..2853436 (-) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW68_RS13320 (MUW68_13320) | 2848386..2849108 | - | 723 | WP_003412957.1 | DUF1906 domain-containing protein | - |
| MUW68_RS13325 (MUW68_13325) | 2849625..2849847 | + | 223 | Protein_2634 | type II toxin-antitoxin system VapB family antitoxin | - |
| MUW68_RS13330 (MUW68_13330) | 2849844..2850245 | + | 402 | WP_003412963.1 | PIN domain-containing protein | - |
| MUW68_RS13335 (MUW68_13335) | 2850280..2851200 | - | 921 | WP_003412965.1 | restriction endonuclease | - |
| MUW68_RS13340 (MUW68_13340) | 2851541..2851786 | - | 246 | WP_071854223.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| MUW68_RS13345 (MUW68_13345) | 2851845..2852795 | + | 951 | WP_003911916.1 | ERCC4 domain-containing protein | - |
| MUW68_RS13350 (MUW68_13350) | 2852796..2853215 | - | 420 | WP_003412970.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MUW68_RS13355 (MUW68_13355) | 2853212..2853436 | - | 225 | WP_003412975.1 | antitoxin VapB39 | Antitoxin |
| MUW68_RS13360 (MUW68_13360) | 2853467..2856310 | - | 2844 | WP_003899363.1 | aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme | - |
| MUW68_RS13365 (MUW68_13365) | 2856382..2856783 | - | 402 | WP_003412981.1 | hypothetical protein | - |
| MUW68_RS13370 (MUW68_13370) | 2856783..2857253 | - | 471 | WP_003899364.1 | transcription antitermination factor NusB | - |
| MUW68_RS13375 (MUW68_13375) | 2857256..2857819 | - | 564 | WP_003412989.1 | elongation factor P | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14732.70 Da Isoelectric Point: 6.7519
>T241172 WP_003412970.1 NZ_CP095023:c2853215-2852796 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL
Download Length: 420 bp
>T241172 NZ_LT960611:c3616246-3615677 [Vibrio tapetis subsp. tapetis]
ATGGCGTCATATACAGTAATTCTAGACGCATGTGTAATGTACCCAGCTCCACTCCGAAGCTACCTAATGTTCTTGGCCAA
TACTGGCCTGTTTAGAGCGCGATGGACAGAACAAATACATGATGAATGGACTCGAAATCTACTGAAAAATAGGCCAGAGC
TAAATGCAGAACAACTGCACAGAACTCGACAGTTAATGAACGCGAATGTTCCAGACTGTTTGATTGAAGGGTTTGAGCCT
TTAATTGATGGCCTTACTTTACCCGATGTTAATGATAGACATGTTGTAGCTGCCGCTATTAAAGGTCAGGCTGAGTCTAT
CATTACGTTCAACCTAAAAGACTTTCCTTCTAGCGAACTCGAGCCTTTAGGTCTATCAGCGATACATCCAGACGAGTTCC
TGTGCGATATGTTTGAATTGGACAGTAGCGCATGCGTTAAGGCTGCTCAGCAACAAAGAGCTTCATTAAAAAGACCACCA
ATGAGCCAAGACGAGTTCTTAGCTTGCTTACAAAAACAGAGACTCCCAAGCTTCGTCTCACACTTAAAGAGCTTCAAGTT
GATGCTTTAA
ATGGCGTCATATACAGTAATTCTAGACGCATGTGTAATGTACCCAGCTCCACTCCGAAGCTACCTAATGTTCTTGGCCAA
TACTGGCCTGTTTAGAGCGCGATGGACAGAACAAATACATGATGAATGGACTCGAAATCTACTGAAAAATAGGCCAGAGC
TAAATGCAGAACAACTGCACAGAACTCGACAGTTAATGAACGCGAATGTTCCAGACTGTTTGATTGAAGGGTTTGAGCCT
TTAATTGATGGCCTTACTTTACCCGATGTTAATGATAGACATGTTGTAGCTGCCGCTATTAAAGGTCAGGCTGAGTCTAT
CATTACGTTCAACCTAAAAGACTTTCCTTCTAGCGAACTCGAGCCTTTAGGTCTATCAGCGATACATCCAGACGAGTTCC
TGTGCGATATGTTTGAATTGGACAGTAGCGCATGCGTTAAGGCTGCTCAGCAACAAAGAGCTTCATTAAAAAGACCACCA
ATGAGCCAAGACGAGTTCTTAGCTTGCTTACAAAAACAGAGACTCCCAAGCTTCGTCTCACACTTAAAGAGCTTCAAGTT
GATGCTTTAA
Antitoxin
Download Length: 75 a.a. Molecular weight: 7993.94 Da Isoelectric Point: 4.0057
>AT241172 WP_003412975.1 NZ_CP095023:c2853436-2853212 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV
Download Length: 225 bp
>AT241172 NZ_LT960611:c3616698-3616246 [Vibrio tapetis subsp. tapetis]
ATGAATACTGCTACAAAATTGCCAAGCGCTGAAGAAATGGCACTGGCTAAGCTTGGTAGCCAAGAGTTGTCAGCCGTTAT
AGAAATTAATGGTGAAGCTCAAAGGATTAATGTTGTCGATAAGTCTGGTAAGACTCACGAGGTAACTATTCCAGCAAGCG
CATTAAATATGATGATCGAGGTGCTTACTCAATTAGGTCAAGGCAACTCTGTTAGCATCACACCTATTCATGCGGAACTC
ACAACGCAAGAAGGTGCTGATATGCTAAACATGTCTCGTCCTACTTTCATTAAGCTTCTTGATTCAGGTGATATTCCGTT
TAGTCGTACTGGCAACCGTAGAAAGGTAGCTTATGCTGATCTTATGGAGTACAAGAACTGCCTAGAAGAGAATAGACTAG
CTGCTCTTGCTGAACTATCTGCATTAGACCAAGAAATGGATATGGGATATTAA
ATGAATACTGCTACAAAATTGCCAAGCGCTGAAGAAATGGCACTGGCTAAGCTTGGTAGCCAAGAGTTGTCAGCCGTTAT
AGAAATTAATGGTGAAGCTCAAAGGATTAATGTTGTCGATAAGTCTGGTAAGACTCACGAGGTAACTATTCCAGCAAGCG
CATTAAATATGATGATCGAGGTGCTTACTCAATTAGGTCAAGGCAACTCTGTTAGCATCACACCTATTCATGCGGAACTC
ACAACGCAAGAAGGTGCTGATATGCTAAACATGTCTCGTCCTACTTTCATTAAGCTTCTTGATTCAGGTGATATTCCGTT
TAGTCGTACTGGCAACCGTAGAAAGGTAGCTTATGCTGATCTTATGGAGTACAAGAACTGCCTAGAAGAGAATAGACTAG
CTGCTCTTGCTGAACTATCTGCATTAGACCAAGAAATGGATATGGGATATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|