Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2806617..2807269 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag MUW68_RS13155 Protein ID WP_003412752.1
Coordinates 2806844..2807269 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag MUW68_RS13150 Protein ID WP_003412749.1
Coordinates 2806617..2806838 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS13135 (MUW68_13135) 2804857..2805063 - 207 WP_003899347.1 hypothetical protein -
MUW68_RS13140 (MUW68_13140) 2805199..2805822 + 624 WP_003900858.1 TIGR00725 family protein -
MUW68_RS13145 (MUW68_13145) 2805812..2806564 + 753 WP_003901416.1 hypothetical protein -
MUW68_RS13150 (MUW68_13150) 2806617..2806838 + 222 WP_003412749.1 antitoxin Antitoxin
MUW68_RS13155 (MUW68_13155) 2806844..2807269 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS13160 (MUW68_13160) 2807292..2808473 - 1182 WP_003905870.1 dihydrolipoamide acetyltransferase family protein -
MUW68_RS13165 (MUW68_13165) 2808470..2809516 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
MUW68_RS13170 (MUW68_13170) 2809527..2810630 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
MUW68_RS13175 (MUW68_13175) 2810889..2811710 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
MUW68_RS13180 (MUW68_13180) 2811707..2812264 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T241171 WP_003412752.1 NZ_CP095023:2806844-2807269 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T241171 NZ_LT960611:2564541-2565842 [Vibrio tapetis subsp. tapetis]
ATGCAAAAACTAAACGCATACATGAACGGAGAACTCGTAGGGACTCTCAATAAACAGAAGAATGGTGCTCATACTTTTCA
GTATGATAAGACCTGGGTAACCAGTGACAAGTCCCGACCACTATCATTGTCTCTAAAATTACAACTTCCACCTATAACTT
CAGACTCAGTCATCAACTACTTCGACAACCTTTTACCTGATAGCCCAAAGGTGAGAGACAGGATCGTAAATCGTTATAAA
GCTTCATCTAAGCAGCCATTCGATCTTCTCAAAGAAGTTGGTAAAGATAGCGTCGGAGCTATTGCATTAATTTCTCCTGA
ACAACCTTACAAAAATGAATCACTCAATTATCAAGTCTTAGATGATAAAAAGTTGGATGCAGTGCTTTCAGCCTACAAAT
CCGATATCCCCCTCGGAATGGTTGAAGAAGAAGAAGATTTCAGAATATCAGTGGCTGGTGTTCAAGAAAAAACGGCACTT
CTATTTCTTGATGAACAGTGGTGTATCCCCAAAGGTAATACTCCAACAACTCATATCATCAAACTACCGATTGGCGAAAT
ACAACAAGCAAACGCAACATTAGATCTTAAAGACAGTGTTGAAAACGAGTACCTTTGCATCGAGTTAGCTAAGGCACTAG
GGTTTGCAGTTCCCAATGTCCACATGCTCAAAACTGATAACCTGAAAGCTTTAGCTGTAGAGCGATTCGATAGACGCTGG
ACTAAAGATAAAGCTAACTTACTCCGTCTACCTCAAGAAGACATGTGCCAAGTATTTGGTATGCCATCATCAATCAAGTA
CGAACCTCAAGGTGGCCCCGGTATTTCGGAAATCATGAAGCTACTCATGGGTTCAAGTAATGCACTGAAAGATCAGTATA
ACTTCATGAAGTTTCAAGTTTTTCAGTGGATTATAGGGGCAACTGATGGGCATGCTAAGAACTATTCTATTTATATTGAG
AAGGGAGGGAGTTATCGTTTAACTCCATTCTACGATATTTTATCAGCATATCCGCTTCTGGGTGGTCGAGGCCTGAATAT
TAGAAAAATCAAGCTCGCAATGGGACTCAAAGCGACTAGAGGGAAAAAGTATGAAATTAACAAAATATTACCTCGCCACT
TTCTGGATACAGCTAAAGCAGTAAACTTCAGCCAAGATAAGATGCAAAAGATATTGAATGAGCTGAAAGGTGAATTCCCC
GAAGCAATCTTACAAGTAAAAGCAAAGCTACCTGAAGATTTCCCTGAGAAGATTTCAGACTCAATTTTTGAAAATGCCAC
AAAGATACTTTCGAAGATTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT241171 WP_003412749.1 NZ_CP095023:2806617-2806838 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT241171 NZ_LT960611:2564293-2564541 [Vibrio tapetis subsp. tapetis]
ATGATATATAGTCCAAAGCAACTCGCTGACATGATGCTCCTAATAAGGCAAAAGAACGGCTGGACTCAATCAGAGTTGGC
CAAAAGGGTAGGCATAAAGCAAGCAACTATCTCAAACTTCGAAAATAGTCCTGATAAGACAACACTTTCGACTTTCTTTA
AACTTATTCAGGCAATGGAGCTGACACTGAGCATCCAGGAAAAAGCACAAGTAAGTTCACAAGATAGCCAAGATGATGAG
AACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References