Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2404583..2405112 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag MUW68_RS11260 Protein ID WP_003411124.1
Coordinates 2404583..2404900 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag MUW68_RS11265 Protein ID WP_003411127.1
Coordinates 2404897..2405112 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS11230 (MUW68_11230) 2399604..2400680 + 1077 WP_003411110.1 hypothetical protein -
MUW68_RS11235 (MUW68_11235) 2400677..2400958 + 282 WP_003411112.1 DUF5703 family protein -
MUW68_RS11240 (MUW68_11240) 2400994..2402067 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
MUW68_RS11245 (MUW68_11245) 2402072..2402602 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
MUW68_RS11250 (MUW68_11250) 2402650..2403996 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
MUW68_RS11260 (MUW68_11260) 2404583..2404900 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUW68_RS11265 (MUW68_11265) 2404897..2405112 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
MUW68_RS11270 (MUW68_11270) 2405367..2406425 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
MUW68_RS11275 (MUW68_11275) 2406555..2406911 - 357 WP_003411130.1 hypothetical protein -
MUW68_RS11280 (MUW68_11280) 2407006..2407788 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
MUW68_RS11285 (MUW68_11285) 2408056..2408346 - 291 WP_003900476.1 YggT family protein -
MUW68_RS11290 (MUW68_11290) 2408508..2409164 - 657 WP_003411133.1 cell division protein SepF -
MUW68_RS11295 (MUW68_11295) 2409230..2410006 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T241170 WP_003411124.1 NZ_CP095023:c2404900-2404583 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T241170 NZ_LT960611:c493257-492967 [Vibrio tapetis subsp. tapetis]
ATGACTTATAAACTCGACTTCAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGTTCTACATTACAGCAGCAATTTAA
AAAAAAGCTAACCGAGCGCCTAGCAAATCCACACGTGCCAGCTTCCAAGCTTTCCGGTGCTGATAACATGTATAAAATTA
AACTACGCCAATCAGGTTACCGCTTAGTGTATAAAGTCGAAGACGATGTAATCATTGTAACCGTCTTAGCTGTGGGGAAA
CGTGAACGTAGCGATGTTTACCGTAAAGCAATGAAACGTATAGATAATTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT241170 WP_003411127.1 NZ_CP095023:c2405112-2404897 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT241170 NZ_LT960611:c493495-493247 [Vibrio tapetis subsp. tapetis]
ATGACCACTAGAATTTTAGCTGATGTTGCTGCAAGTATTACCGAATTAAAAGCAAATCCAATGAAGGTTGCAACTAGTGC
TTACGGTGAACCTGTTGCTGTGCTTAACCGAAATGAACCCGCATTCTACTGTGTACCTGCTGAAGCATACGAAATGATGA
TGGACAGACTCGAAGATCTAGAGCTACTTACTATTGCTAAAGAACGTGAATCTGAAGAGAGCATTTCGGTAAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References