Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2367663..2368358 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag MUW68_RS11050 Protein ID WP_003410811.1
Coordinates 2367663..2368097 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag MUW68_RS11055 Protein ID WP_003410814.1
Coordinates 2368104..2368358 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS11040 (MUW68_11040) 2363817..2366858 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
MUW68_RS11045 (MUW68_11045) 2366851..2367684 + 834 WP_003899172.1 SWIM zinc finger family protein -
MUW68_RS11050 (MUW68_11050) 2367663..2368097 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS11055 (MUW68_11055) 2368104..2368358 - 255 WP_003410814.1 antitoxin Antitoxin
MUW68_RS11060 (MUW68_11060) 2368374..2368631 - 258 WP_003410816.1 hypothetical protein -
MUW68_RS11065 (MUW68_11065) 2369578..2369874 + 297 WP_003410820.1 PE family protein -
MUW68_RS11070 (MUW68_11070) 2369930..2370661 + 732 WP_003900467.1 PPE family protein -
MUW68_RS11075 (MUW68_11075) 2371201..2371947 - 747 WP_003901330.1 proteasome subunit alpha -
MUW68_RS11080 (MUW68_11080) 2371944..2372819 - 876 WP_003411023.1 proteasome subunit beta -
MUW68_RS11085 (MUW68_11085) 2372816..2373010 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T241169 WP_003410811.1 NZ_CP095023:c2368097-2367663 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T241169 NZ_LT934425:c4385585-4385304 [Candidatus Kuenenia stuttgartiensis]
ATGATAAAAAACTTTGCTTGCAAAGAAACAGAGAAAATATTCAATCGTCGAATATCACTCAAACTTCCACGGGATATACA
AAAAACTGCCCGAAGAAAACTTGAAATACTTGAAGGTGCTGAAATCCTGATGGATTTACGTATACCACCGAATAATCATC
TTGAAAAACTATCGAAAGATAGGAATGGGCAATATAGTATCCGTATTAATGATCAATGGCGTATATGTTTTGAATGGCGT
GGAGGAGATGCTTACAACGTTGAAATAGTAGATTATCATTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT241169 WP_003410814.1 NZ_CP095023:c2368358-2368104 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT241169 NZ_LT934425:c4385294-4384989 [Candidatus Kuenenia stuttgartiensis]
ATGGCAAAAAAGATATTAGATCCAATTCATCCAGGTGAAATTCTGATGGAAGAATTTCTCAAACCCATGGGTATTAGTCA
GTACCGGCTGGCTAAAGATATTAATGTACCTGCACGCAGAATAAATGAGATTGTTCAGGGCAAACGTTCTGTAACTCCAG
ATACAGCTTTAAGACTATCAAGGTTTTTTGGTCTTTCAGAAAGGTTTTGGATAAATCTTCAAGCAAGATATGATCTTGAA
ATAGAAAAAGATAGATTAAAGAATCGCCTTGATGAAGAGGTGCATGTTTACACTTCTGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References