Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2228716..2229302 | Replicon | chromosome |
| Accession | NZ_CP095023 | ||
| Organism | Mycobacterium tuberculosis strain SGF0702019 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G0TLY3 |
| Locus tag | MUW68_RS10445 | Protein ID | WP_003410010.1 |
| Coordinates | 2228716..2229060 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL58 |
| Locus tag | MUW68_RS10450 | Protein ID | WP_003410014.1 |
| Coordinates | 2229054..2229302 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUW68_RS10410 (MUW68_10410) | 2224422..2225021 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
| MUW68_RS10415 (MUW68_10415) | 2225437..2225865 | + | 429 | WP_003409992.1 | cellulose-binding protein | - |
| MUW68_RS10420 (MUW68_10420) | 2226091..2226630 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| MUW68_RS10425 (MUW68_10425) | 2227150..2227710 | - | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | - |
| MUW68_RS10430 (MUW68_10430) | 2227707..2228048 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | - |
| MUW68_RS10435 (MUW68_10435) | 2228134..2228391 | + | 258 | WP_003410006.1 | hypothetical protein | - |
| MUW68_RS10440 (MUW68_10440) | 2228292..2228627 | - | 336 | WP_003410009.1 | dehydrogenase | - |
| MUW68_RS10445 (MUW68_10445) | 2228716..2229060 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | Toxin |
| MUW68_RS10450 (MUW68_10450) | 2229054..2229302 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| MUW68_RS10455 (MUW68_10455) | 2229402..2231717 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| MUW68_RS10460 (MUW68_10460) | 2231714..2231986 | - | 273 | WP_003410017.1 | DUF1490 family protein | - |
| MUW68_RS10465 (MUW68_10465) | 2232039..2232395 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
| MUW68_RS10470 (MUW68_10470) | 2232552..2233319 | + | 768 | WP_003410019.1 | hemerythrin domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12230.12 Da Isoelectric Point: 9.8887
>T241165 WP_003410010.1 NZ_CP095023:c2229060-2228716 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
Download Length: 345 bp
>T241165 NZ_LT934425:1210361-1210567 [Candidatus Kuenenia stuttgartiensis]
ATGCAAATGCGCGCATTTGCAAAGCTCAATGCGATTGATGCAGCCATCCATCTTAAAGATTTGCACCTGCCACCATCAAA
CCGGTTTGAGGCGTTAAAGGGCGAACGTAAGGAGCAGTATAGCATTCGAATCAATGATAGATGGCGTATTTGTTTTGAGT
GGCGTAATGGTAACGCAGAAGAGGTCGAAATTGTTGATTATCATTAA
ATGCAAATGCGCGCATTTGCAAAGCTCAATGCGATTGATGCAGCCATCCATCTTAAAGATTTGCACCTGCCACCATCAAA
CCGGTTTGAGGCGTTAAAGGGCGAACGTAAGGAGCAGTATAGCATTCGAATCAATGATAGATGGCGTATTTGTTTTGAGT
GGCGTAATGGTAACGCAGAAGAGGTCGAAATTGTTGATTATCATTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9290.34 Da Isoelectric Point: 4.3757
>AT241165 WP_003410014.1 NZ_CP095023:c2229302-2229054 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
Download Length: 249 bp
>AT241165 NZ_LT934425:1210580-1210894 [Candidatus Kuenenia stuttgartiensis]
ATGGCTAAACGTCGTATTACTCCAGTTCACCCTGGGGTATATCTGAAAGAATTACTCGATGAATTAAAAATATCACAATA
CCGGCTATCACAGGATTTAGGTGTGCCTGCCATGAGGATCAATCATGTGGTACATAGCAAACGTCCGGTAACTGCAGAGC
TTGCCTTGCGTTTAGGGCGCTATTTTGGTCAAAGCCCGCGCTATTGGATGAACCTGCAAAGCCGGTATGATATGGATATT
GCCGAAGATGCCTTATTCGAACAGGTAACACGTGAAGTTCGCCCCTTTAACGGTAGATTTATAATTCACAAGTAA
ATGGCTAAACGTCGTATTACTCCAGTTCACCCTGGGGTATATCTGAAAGAATTACTCGATGAATTAAAAATATCACAATA
CCGGCTATCACAGGATTTAGGTGTGCCTGCCATGAGGATCAATCATGTGGTACATAGCAAACGTCCGGTAACTGCAGAGC
TTGCCTTGCGTTTAGGGCGCTATTTTGGTCAAAGCCCGCGCTATTGGATGAACCTGCAAAGCCGGTATGATATGGATATT
GCCGAAGATGCCTTATTCGAACAGGTAACACGTGAAGTTCGCCCCTTTAACGGTAGATTTATAATTCACAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|