Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2227150..2228048 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag MUW68_RS10425 Protein ID WP_003410001.1
Coordinates 2227150..2227710 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag MUW68_RS10430 Protein ID WP_003410003.1
Coordinates 2227707..2228048 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS10395 (MUW68_10395) 2222319..2222972 - 654 WP_003409976.1 cutinase Cfp21 -
MUW68_RS10400 (MUW68_10400) 2223087..2223317 + 231 WP_003409980.1 DUF167 domain-containing protein -
MUW68_RS10405 (MUW68_10405) 2223402..2224313 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MUW68_RS10410 (MUW68_10410) 2224422..2225021 + 600 WP_003409989.1 L-lysine exporter -
MUW68_RS10415 (MUW68_10415) 2225437..2225865 + 429 WP_003409992.1 cellulose-binding protein -
MUW68_RS10420 (MUW68_10420) 2226091..2226630 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MUW68_RS10425 (MUW68_10425) 2227150..2227710 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
MUW68_RS10430 (MUW68_10430) 2227707..2228048 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
MUW68_RS10435 (MUW68_10435) 2228134..2228391 + 258 WP_003410006.1 hypothetical protein -
MUW68_RS10440 (MUW68_10440) 2228292..2228627 - 336 WP_003410009.1 dehydrogenase -
MUW68_RS10445 (MUW68_10445) 2228716..2229060 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
MUW68_RS10450 (MUW68_10450) 2229054..2229302 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
MUW68_RS10455 (MUW68_10455) 2229402..2231717 - 2316 WP_003899120.1 cation transporter ATPase CptG -
MUW68_RS10460 (MUW68_10460) 2231714..2231986 - 273 WP_003410017.1 DUF1490 family protein -
MUW68_RS10465 (MUW68_10465) 2232039..2232395 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T241164 WP_003410001.1 NZ_CP095023:c2227710-2227150 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T241164 NZ_LT907990:c433311-433033 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT241164 WP_003410003.1 NZ_CP095023:c2228048-2227707 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT241164 NZ_LT907990:c433592-433308 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References