Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2219824..2220512 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag MUW68_RS10380 Protein ID WP_003409958.1
Coordinates 2219824..2220243 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MUW68_RS10385 Protein ID WP_003409968.1
Coordinates 2220252..2220512 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS10360 (MUW68_10360) 2215319..2216167 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
MUW68_RS10365 (MUW68_10365) 2216130..2217575 - 1446 WP_003899115.1 APC family permease -
MUW68_RS10370 (MUW68_10370) 2217754..2218440 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
MUW68_RS10375 (MUW68_10375) 2218631..2219599 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MUW68_RS10380 (MUW68_10380) 2219824..2220243 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS10385 (MUW68_10385) 2220252..2220512 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUW68_RS10390 (MUW68_10390) 2220655..2222331 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
MUW68_RS10395 (MUW68_10395) 2222319..2222972 - 654 WP_003409976.1 cutinase Cfp21 -
MUW68_RS10400 (MUW68_10400) 2223087..2223317 + 231 WP_003409980.1 DUF167 domain-containing protein -
MUW68_RS10405 (MUW68_10405) 2223402..2224313 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MUW68_RS10410 (MUW68_10410) 2224422..2225021 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T241163 WP_003409958.1 NZ_CP095023:c2220243-2219824 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T241163 NZ_LT907990:431040-431309 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT241163 WP_003409968.1 NZ_CP095023:c2220512-2220252 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT241163 NZ_LT907990:431303-431824 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References