Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1942944..1943557 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag MUW68_RS09055 Protein ID WP_003408465.1
Coordinates 1942944..1943333 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag MUW68_RS09060 Protein ID WP_003408469.1
Coordinates 1943330..1943557 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS09020 (MUW68_09020) 1938573..1939487 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
MUW68_RS09025 (MUW68_09025) 1939490..1940320 + 831 WP_003408448.1 cyclase family protein -
MUW68_RS09030 (MUW68_09030) 1940320..1940670 + 351 WP_003898986.1 cupin domain-containing protein -
MUW68_RS09035 (MUW68_09035) 1940723..1941541 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
MUW68_RS09040 (MUW68_09040) 1941555..1942334 + 780 WP_003408460.1 IclR family transcriptional regulator -
MUW68_RS09050 (MUW68_09050) 1942765..1942896 + 132 Protein_1786 IS3 family transposase -
MUW68_RS09055 (MUW68_09055) 1942944..1943333 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS09060 (MUW68_09060) 1943330..1943557 - 228 WP_003408469.1 antitoxin Antitoxin
MUW68_RS09065 (MUW68_09065) 1943775..1945259 + 1485 WP_003408473.1 biotin carboxylase -
MUW68_RS09070 (MUW68_09070) 1945256..1946503 + 1248 WP_003408476.1 serine hydrolase -
MUW68_RS09075 (MUW68_09075) 1946546..1946965 - 420 WP_003408483.1 hypothetical protein -
MUW68_RS09080 (MUW68_09080) 1946955..1947665 - 711 WP_244733080.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T241158 WP_003408465.1 NZ_CP095023:c1943333-1942944 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T241158 NZ_LT907990:420239-420526 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT241158 WP_003408469.1 NZ_CP095023:c1943557-1943330 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT241158 NZ_LT907990:419998-420249 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References