Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1691516..1692132 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag MUW68_RS07955 Protein ID WP_003407593.1
Coordinates 1691815..1692132 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag MUW68_RS07950 Protein ID WP_003900349.1
Coordinates 1691516..1691818 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS07940 (MUW68_07940) 1687402..1689249 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
MUW68_RS07945 (MUW68_07945) 1689250..1691502 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
MUW68_RS07950 (MUW68_07950) 1691516..1691818 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
MUW68_RS07955 (MUW68_07955) 1691815..1692132 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
MUW68_RS07960 (MUW68_07960) 1692129..1693133 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
MUW68_RS07965 (MUW68_07965) 1693186..1694475 + 1290 WP_003902090.1 serine hydrolase domain-containing protein -
MUW68_RS07970 (MUW68_07970) 1694548..1695273 - 726 WP_003898898.1 class I SAM-dependent methyltransferase -
MUW68_RS07975 (MUW68_07975) 1695379..1695591 - 213 WP_003898900.1 dodecin family protein -
MUW68_RS07980 (MUW68_07980) 1695652..1696050 + 399 WP_003900351.1 hypothetical protein -
MUW68_RS07985 (MUW68_07985) 1696095..1697123 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T241156 WP_003407593.1 NZ_CP095023:1691815-1692132 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T241156 NZ_LT907990:414947-415279 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT241156 WP_003900349.1 NZ_CP095023:1691516-1691818 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT241156 NZ_LT907990:415266-415580 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References