Detailed information of TA system TA241152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1386243..1386931
• Replicon: chromosome
• Accession: NZ_CP095023
• Organism: Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: MUW68_RS06610
• Protein ID: WP_003406304.1
• Coordinates: 1386500..1386931 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: MUW68_RS06605
• Protein ID: WP_003406302.1
• Coordinates: 1386243..1386503 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW68_RS06585 (MUW68_06585)	1381820..1382644	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
MUW68_RS06590 (MUW68_06590)	1382649..1383830	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
MUW68_RS06595 (MUW68_06595)	1383907..1385007	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
MUW68_RS06600 (MUW68_06600)	1385178..1386167	+	990	WP_003406301.1	malate dehydrogenase	-
MUW68_RS06605 (MUW68_06605)	1386243..1386503	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
MUW68_RS06610 (MUW68_06610)	1386500..1386931	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUW68_RS06615 (MUW68_06615)	1386954..1388537	-	1584	WP_244733059.1	PE family protein	-
MUW68_RS06620 (MUW68_06620)	1388717..1389577	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
MUW68_RS06625 (MUW68_06625)	1389658..1390488	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
MUW68_RS06630 (MUW68_06630)	1390545..1390838	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
MUW68_RS06635 (MUW68_06635)	1390835..1391104	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T241152 WP_003406304.1 NZ_CP095023:1386500-1386931 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T241152 NZ_LT907990:c349925-349626 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT241152 WP_003406302.1 NZ_CP095023:1386243-1386503 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT241152 NZ_LT907990:c350164-349922 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6