Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 842939..843648 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag MUW68_RS03960 Protein ID WP_003403837.1
Coordinates 843220..843648 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag MUW68_RS03955 Protein ID WP_003403834.1
Coordinates 842939..843196 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS03950 (MUW68_03950) 840575..842848 + 2274 WP_016330384.1 PE family protein -
MUW68_RS03955 (MUW68_03955) 842939..843196 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
MUW68_RS03960 (MUW68_03960) 843220..843648 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS03965 (MUW68_03965) 843729..843866 - 138 WP_003403839.1 hypothetical protein -
MUW68_RS03975 (MUW68_03975) 844025..844270 + 246 WP_003403841.1 hypothetical protein -
MUW68_RS03980 (MUW68_03980) 844339..845223 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
MUW68_RS03985 (MUW68_03985) 845234..846406 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
MUW68_RS03990 (MUW68_03990) 846413..847945 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T241147 WP_003403837.1 NZ_CP095023:843220-843648 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T241147 NZ_LT907990:c322999-322682 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT241147 WP_003403834.1 NZ_CP095023:842939-843196 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT241147 NZ_LT907990:c323260-323018 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References