Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 756804..757596 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag MUW68_RS03480 Protein ID WP_003403386.1
Coordinates 757159..757596 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag MUW68_RS03475 Protein ID WP_003403381.1
Coordinates 756804..757049 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS03445 (MUW68_03445) 751824..753329 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
MUW68_RS03450 (MUW68_03450) 753410..754420 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
MUW68_RS03455 (MUW68_03455) 754808..755191 - 384 WP_003403365.1 ribonuclease VapC6 -
MUW68_RS03460 (MUW68_03460) 755286..755441 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
MUW68_RS03465 (MUW68_03465) 755517..756233 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
MUW68_RS03470 (MUW68_03470) 756509..756817 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
MUW68_RS03475 (MUW68_03475) 756804..757049 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
MUW68_RS03480 (MUW68_03480) 757159..757596 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS03485 (MUW68_03485) 757593..757847 - 255 WP_003911263.1 antitoxin VapB7 -
MUW68_RS03490 (MUW68_03490) 757961..760324 + 2364 WP_003901895.1 arylsulfatase AtsD -
MUW68_RS03495 (MUW68_03495) 760387..760713 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MUW68_RS03500 (MUW68_03500) 760625..760963 + 339 WP_003403405.1 PIN domain-containing protein -
MUW68_RS03505 (MUW68_03505) 760960..761133 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T241145 WP_003403386.1 NZ_CP095023:c757596-757159 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T241145 NZ_LT907988:3729462-3729887 [Orrella dioscoreae]
ATGCAGAAGTGGATGCTCGATACCAACATTTGCATCTACACCATCAAGAACAGACCCGAACGTGTTCGCCACGCGTTCAA
CCAGCGCTCGAGCAGTCTCTGCATCAGTACGATTTCCGCGATGGAACTGGTATACGGCGCGGAGAAATCCGCGTCCCCCG
CCCGCAACCTCGCCACAGTGGAAGGTTTTCTGGCCCGCCTGGACGTCCTCGACTATGACCGCGCCGCCGCGATCAATACT
GGTCAACTGCGCGCCGAGCTGGCCCAGGCCGGCACGCCCATCGGCGCCTACGATGCCATGATCGCGGGACATGCGCGTTC
CAGGGGTTTCGTGCTGGTCAGCAACAACACCCGCGAATTCACCCGTGTACCGGGCCTGCGCCTGGAGGATTGGGCCCTGG
GACCTGAAGACACCCCCCCCCTCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT241145 WP_003403381.1 NZ_CP095023:c757049-756804 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT241145 NZ_LT907988:3729232-3729462 [Orrella dioscoreae]
ATGGAACAAGGTGCCATCTTCAAAAGCAACCGAAGCCAGGCCGTCCGACTGCCCAAGGCAGCGGCCATGCCCGAAGGCGT
CACACGCGTAGATATCCTCAGCATCGGGCGTACCCGCATCCTGGCGCCCGCCGGCGAAGCCTGGGACAGTTGGTTCCAGG
CGGAAGGTGCCAGTGCCGACTTCATGGATACCCGAGACCAGCCCGCGGATCAGCACCGGGAGACCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References