Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 754808..755441 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag MUW68_RS03455 Protein ID WP_003403365.1
Coordinates 754808..755191 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag MUW68_RS03460 Protein ID WP_003403368.1
Coordinates 755286..755441 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS03430 (MUW68_03430) 750100..750636 + 537 WP_003403341.1 50S ribosomal protein L10 -
MUW68_RS03435 (MUW68_03435) 750673..751065 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
MUW68_RS03440 (MUW68_03440) 751058..751753 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
MUW68_RS03445 (MUW68_03445) 751824..753329 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
MUW68_RS03450 (MUW68_03450) 753410..754420 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
MUW68_RS03455 (MUW68_03455) 754808..755191 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
MUW68_RS03460 (MUW68_03460) 755286..755441 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MUW68_RS03465 (MUW68_03465) 755517..756233 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
MUW68_RS03470 (MUW68_03470) 756509..756817 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
MUW68_RS03475 (MUW68_03475) 756804..757049 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
MUW68_RS03480 (MUW68_03480) 757159..757596 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
MUW68_RS03485 (MUW68_03485) 757593..757847 - 255 WP_003911263.1 antitoxin VapB7 -
MUW68_RS03490 (MUW68_03490) 757961..760324 + 2364 WP_003901895.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T241143 WP_003403365.1 NZ_CP095023:c755191-754808 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T241143 NZ_LT907988:3476998-3477405 [Orrella dioscoreae]
ATGCGCTATCTGCTGGACACCAACATCCTGATCTACCTGATCAAGCACAGGCCTCCCTCCGTCGCGGAACGCATTGCCCA
ACTGGCGCTGGATGACGCGCTCCATATGTCGTTCGTCAGTTGGGCCGAACTGCTGAAAGGCGCAGAACGCAGCACGCGCG
CGGACACAGTGCGCAAGCAACTCCATAAATTGGCGCAGCACATACCGGTACTCTACGAAACCAGCCACGACATGTGCCTG
CACCATGCGAGGCTGGGCGCCATGTTCAAGTCACAGGGAAAGCCGATCGGCGCCAACGACCTGTGGATTGCCGCTCATGC
GTTGGCAGAGGGGTGTGTACTCGTCACCAACAATACGCGCGAATTTTCACGCGTGCCTGGTTTACCCTTGCAGAATTGGG
TCCAATGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT241143 WP_003403368.1 NZ_CP095023:c755441-755286 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT241143 NZ_LT907988:3476711-3476998 [Orrella dioscoreae]
ATGCCCACCACGCTCACAAGCCGCATCTTCAACAACGGCAACAGCCAGGCTGTCCGCATCCCTCTTGCCTTCAGATTGGA
TGCCCAACGCGTGAGCATCACACGCAAGGAAAACGGCGACCTGCTGCTGCATCCACTCCCCGATGCGCCCGCTGATCGCG
CTGCCGCCATCCAGGCGGCGCTGCAGGGCTTCGGCGAACTCGATGACGCCACGCAGCGCGCATTCATCGCCGAACTGGAA
GGCAATCGCGCGCAACCCGAGCCGGACCAGGAGCGGGAAGCCTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References