Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 719325..719989 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag MUW68_RS03285 Protein ID WP_003403246.1
Coordinates 719582..719989 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF18
Locus tag MUW68_RS03280 Protein ID WP_003403244.1
Coordinates 719325..719585 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS03255 (MUW68_03255) 715502..716566 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MUW68_RS03260 (MUW68_03260) 716670..717617 + 948 WP_003403232.1 DUF732 domain-containing protein -
MUW68_RS03265 (MUW68_03265) 717710..717964 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
MUW68_RS03270 (MUW68_03270) 717964..718359 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
MUW68_RS03275 (MUW68_03275) 718453..719193 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
MUW68_RS03280 (MUW68_03280) 719325..719585 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUW68_RS03285 (MUW68_03285) 719582..719989 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS03290 (MUW68_03290) 720061..721212 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MUW68_RS03295 (MUW68_03295) 721305..723032 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T241142 WP_003403246.1 NZ_CP095023:719582-719989 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

>T241142 NZ_LT907988:3416825-3417118 [Orrella dioscoreae]
ATGCCCAAGACATCCACCCGCCCATACGACGTCGCCGAACATCTACGCACGCCAAGAGAAATGGCGCTGTATCTGGATGC
CTGCATCGAGGAAAGCGATGGCGATGCTGCCTTCATTGCCAAGGCGTTGGGAGATGTTGCACGTGCGCAGGGCATGAGCA
AGGTGGCGCGGGAAACAGGCTTATCGCGAGAGAGCCTCTACAAATCATTGTCCGGAGAGCGCGAACCCGACTTTTCCACG
GTGCTGAAAGTCCTGAAAGCCTTGGGGATCCGCTTTCACGCCATCCCGGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9492.84 Da        Isoelectric Point: 11.9108

>AT241142 WP_003403244.1 NZ_CP095023:719325-719585 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT241142 NZ_LT907988:3416547-3416768 [Orrella dioscoreae]
CTGAACCAGGCGCGGGTCCAGCGCCTGGCCCTTGGCAATCCAGGCGACCATCGCGGACTGCAGCACGGTGTGAAAGAGTT
GCGCATCCATGTCGGACCTGGATATCGCGTCTATTACACCGAGCGCGATACCAACACCCTCGTGGTTCTGCTTGCGGGCG
GGGACAAATCGACGCAGCAGGCAGATATCGCGCTGGCCTATCTGCTGGCAACAAGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure
PDB 3DBO
AlphaFold DB A0A7U4BSE4

References